- Basic information
- CohesinDB ID: CDBP00413633
- Locus: chr21-16004906-16005266
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Data sourse: GSE206145, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
42% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 99%,
"5_TxWk": 1%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF394, FOXO1, TRP47, NANOG, SMC1A, PGR, CHD8, TOP2A, ZFX, STAG2, XBP1, ZBTB48, FOXA1, ZNF654, SRF, HOXB13, SMARCC1, KDM1A, ERG, RELA, ZBTB2, ZNF384, NEUROD1, MYC, GATA4, SMARCA4, RAD21, ISL1, FOXP2, HIF1A, GRHL3, OTX2, GATA3, NKX2-1, TAL1, NKX3-1, GATA1, RCOR1, HAND2, NR3C1, TEAD1, PIAS1, KDM5B, EZH2, ESR1, EBF3, PHOX2B, CTCF, JUN, BAF155, BCL11A, AR, GATA2, RFX5, NOTCH3, BRD4, FOXP1, SMC1, MRTFB, SMC3, TBX2, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): USP25
- Function elements
- Human SNPs: Reaction_time
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000155313,
- Related loop:
chr21:15875000-15900000~~chr21:16000000-16025000,
chr21:15975000-16000000~~chr21:16175000-16200000,
chr21:15975000-16000000~~chr21:16325000-16350000,
chr21:15975000-16000000~~chr21:26225000-26250000,
chr21:15975000-16000000~~chr21:28150000-28175000,
chr21:16000000-16025000~~chr21:16175000-16200000,
chr21:16000000-16025000~~chr21:16325000-16350000,
chr21:16000000-16025000~~chr21:16400000-16425000,
chr21:16000000-16025000~~chr21:17250000-17275000,
chr21:16001839-16003762~~chr21:16329724-16331264,
chr21:16001977-16003846~~chr21:16329691-16331745,
chr21:16001998-16003844~~chr21:16329695-16331504,
chr21:16002031-16003807~~chr21:16329708-16331692,
chr21:16002041-16004416~~chr21:16329708-16331761,
chr21:16002066-16003798~~chr21:16329704-16331395,
chr21:16002070-16004771~~chr21:16329660-16331732,
chr21:16002137-16004536~~chr21:16329715-16331630,
chr21:16002506-16003755~~chr21:16329734-16331645,