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Basic information

CohesinDB ID: CDBP00413644

Locus: chr21-16069741-16074239

Data sourse: GSE116868, ENCSR000BLY, ENCSR000ECS, GSE25021, ENCSR000BUC, ENCSR917QNE, GSE165895, ENCSR000BTU, GSE86191, GSE115250, GSE138405, GSE101921, GSE152721, GSE206145-NatGen2015, GSE112028, GSE94872, ENCSR193NSH, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR984DZW, ENCSR217ELF, GSE131956, ENCSR000EDE, GSE126990, ENCSR748MVX

Cell type: Liver, TC-32, RPE, Fibroblast, Ishikawa, HeLa-S3, HFFc6, MB157, GBM39, SK-N-SH, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, HEK293T, A-549, HUVEC, HCAEC, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 42% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 46%, "7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZNF660, SOX2, NME2, XBP1, FOXA1, ZNF90, NFIC, ZBTB44, CHD7, CDX2, MAF, KLF5, TEAD1, ZNF573, ESR1, HNF1B, PITX3, JUN, CTCF, TCF12, BAF155, EP300, RFX5, E2F1, TEAD4, RBPJ, GLIS1, POU2F2, CHD8, POU5F1, MYCN, TOP2A, ZBTB17, DUX4, SRF, ERG, HOXC5, ASCL1, MYC, SMARCA4, RAD21, FOXP2, TOP1, GABPA, STAT3, RCOR1, NR3C1, CEBPB, CREB1, EBF3, ZNF257, GATA2, FLI1, MXI1, HEXIM1-CDK9, MRTFB, MYF5, CTNNB1, ZBTB24, CEBPA, SIN3A, ZNF534, POU4F2, ERG3, SMARCC1, TWIST1, CREBBP, RUNX2, CDK6, PBX4, ARNT, ATF2, PBX3, FOS, CHD1, MED1, PIAS1, KLF9, ZNF41, NUP98-HOXA9, USF1, REST, POU2F3, STAG1, PAX7, FOXA2, TBL1X, CHD2, SS18, ZSCAN16, ZNF692, FOXF1, HOXB13, KDM1A, YY1, RELA, JUNB, BRG1, ISL1, HIF1A, OTX2, GATA3, MAX, HAND2, NR2F2, TCF7L2, NEUROG2, TP53, PKNOX1, ZNF334, PHOX2B, BHLHE40, AR, PAX3-FOXO1, TAF1, EGLN2, NOTCH3, JUND, BRD4, MAZ, TBX2, BRCA1, FOSL2

Target gene symbol (double-evidenced CRMs): HSPA13

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 52

Related genes and loops

Related gene: ENSG00000155304,

eachgene

Deatailed information for cohesin site CDBP00413644