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Basic information

CohesinDB ID: CDBP00413647

Locus: chr21-16080918-16087159

Data sourse: ENCSR230ZWH, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, ENCSR676MJK, GSE155324, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE62063, ENCSR807WAC, ENCSR981FDC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, SLK, GM19240, Liver, TC-32, HuCC-T1, H9-hESC, B-cell, GM2630, HMEC, Fibroblast, RPE, HEKn, Ishikawa, GM12890, HeLa-S3, IMR-90, K-562, GM18486, HFFc6, H1-hESC, SNYDER, Monocytes, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, HeLa-Tet-On, GM19193, THP-1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 54% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.422

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 42% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 49%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, ZNF660, NME2, PATZ1, FOXA1, HLF, PBX2, RXRB, ATF3, NFIC, ZBTB44, CHD7, IKZF3, MXD4, ZNF189, HDAC3, CDX2, ZNF629, TEAD1, ZNF26, KLF6, ETV1, RCOR2, ESR1, HNF1B, JUN, TCF12, CTCF, BAF155, EP300, SOX5, IRF4, RFX5, E2F1, SMC1, FOXA3, GATAD2A, PDX1, NANOG, CHD8, BRD3, CTBP1, ZSCAN21, ZBTB17, DUX4, ERF, SRF, GATAD1, SAP130, HIC1, ARID3A, TBP, HNF4G, HOXC5, ERG, PAX6, ZNF300, MYC, SMARCA4, TSHZ1, HOMEZ, RAD21, TOP1, RXRA, NKX2-1, GABPA, STAT3, ZNF614, NKX3-1, ZNF639, VDR, NR3C1, CEBPB, ESRRA, CREB1, TBL1XR1, EZH2, KLF8, FEZF1, GRHL2, ZNF664, MIXL1, IRF1, HDAC2, GATA2, ZNF644, ZGPAT, NFIL3, NFYB, ZIM3, MRTFB, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, LDB1, SOX13, SMAD3, ZFP37, ZNF654, TBX3, ERG3, SMARCC1, MYBL2, CREBBP, RARA, ZNF384, ZBTB2, RUNX2, GATA4, OSR2, GR, ZNF184, SP3, ARNT, PBX4, DAXX, PRDM9, ZEB2, SMAD4, FOXM1, FOS, CHD1, MED1, CSNK2A1, ZEB1, TEAD3, CEBPD, PIAS1, SMAD1, ZNF3, KLF9, NUP98-HOXA9, MAFK, SP1, BCL11A, HNF4A, REST, ARID1A, ZNF479, ATF7, ZHX1, ASH2L, PHIP, FOXP1, SMC3, STAG1, ZNF394, SKI, FOXA2, CREM, SS18, ZSCAN16, ZNF692, TCF7, HOXB13, BCL3, KDM1A, YY1, RELA, JUNB, BRG1, HIF1A, OTX2, GATA3, TAL1, MAX, TLE3, KLF4, CEBPG, SP7, TP53, PKNOX1, PHOX2B, ELF3, PHF5A, BRD2, NFKBIZ, AR, ARID4B, ZNF366, BRD4, JUND, CUX1, BRCA1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): USP25

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413647