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Basic information

CohesinDB ID: CDBP00413670

Locus: chr21-16182009-16182569

Data sourse: GSE62063, GSE120943, GSE98367

Cell type: Monocytes, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: NIPBL,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 42% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 81%, "5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, NME2, FOXA1, MLL4, LYL1, ZBTB44, PRDM1, CHD7, MITF, HDAC3, SFPQ, TEAD1, TRIM28, ZNF121, ETV1, NFE2L2, LMO2, ESR1, JUN, TCF12, CTCF, BAF155, EP300, PRDM4, IRF4, E2F1, TEAD4, TFAP2C, NANOG, BRD3, CTBP1, STAT1, HIC1, ERG, MYC, SMARCA4, TOP1, RAD21, NKX2-1, GABPA, NKX3-1, NFE2, VDR, NR3C1, CEBPB, CREB1, GRHL2, TRPS1, SPI1, HDAC2, GATA2, FLI1, NCOA2, RUNX1, SIN3A, AFF4, ZFP37, ERG3, SMARCC1, CREBBP, GATA4, GR, NRF1, ARNT, PRDM9, FOXM1, FOS, MED1, TEAD3, SCRT2, PIAS1, EVI1, MAFK, SP1, NIPBL, BCL11A, REST, POU2F3, ASH2L, CTBP2, PHIP, FOXP1, SMC3, ELL2, ZNF394, FOXA2, SS18, ZSCAN16, GTF2B, CDK9, HOXB13, YY1, RELA, NEUROD1, JUNB, BRG1, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, TLE3, NCOA3, NR2F2, NR2F1, TCF7L2, TP53, BRD2, AR, EGLN2, SCRT1, BRD4, JUND, BRCA1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): USP25,NRIP1,HSPA13

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000180530, ENSG00000155313,

Tools:

Assay

refGene

Ruler

Cohesin site CDBP00413670

CDBP00413670 regulated genes

Related cohesin loop

Deatailed information for cohesin site CDBP00413670

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