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Basic information

CohesinDB ID: CDBP00413676

Locus: chr21-16192814-16197732

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE126634, GSE116868, ENCSR760NPX, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE111537, GSE25021, ENCSR330ELC, GSE108869, GSE62063, ENCSR000BUC, ENCSR917QNE, GSE165895, ENCSR000BTU, ENCSR000DZP, ENCSR000EAC, GSE115250, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE152721, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE94872, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR807WAC, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, ENCSR676MJK, GSE38411, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: RH4, GM2610, SLK, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, BCBL-1, GM18486, HFFc6, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, HeLa-Tet-On, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, HeLa, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 45% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.533

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 42% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "1_TssA": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, CBX5, PGR, HMG20A, ZNF660, SOX2, NME2, PATZ1, FOXA1, ZNF101, RXRB, ZFHX2, ATF3, NFIC, ZFP64, ZNF362, CTCFL, RUNX3, ZBTB44, CHD7, PRDM1, IKZF3, CBFB, ZNF273, ZNF189, ZSCAN4, ZNF84, SFPQ, INTS11, JMJD1C, KLF5, TEAD1, TRIM28, ZNF629, KLF6, ELF1, NFE2L2, KLF10, BCLAF1, ESR1, HNF1B, SMAD5, ETV1, ZNF561, CTCF, JUN, TCF12, BAF155, EP300, ZNF695, GATA6, SOX5, SOX4, E2F6, PRDM4, TRIM24, RFX5, IRF4, DEK, E2F4, E2F1, SMC1, ZNF280A, TEAD4, KMT2B, FOXA3, GTF2F1, PDX1, TFAP2C, EED, RBPJ, NANOG, CHD8, POU5F1, MYCN, ZNF263, BRD3, CDK7, ZSCAN21, ZBTB17, DUX4, ZBTB48, STAT1, ZNF317, SRF, SAP130, ERG2, HIC1, TBP, ERG, HOXC5, ZBTB21, CHD4, PBX1, ETS1, MYC, ONECUT1, SMARCA4, EOMES, ZNF671, RAD21, ZKSCAN2, GRHL3, MYOG, TOP1, RXRA, NKX2-1, LHX2, GABPA, STAT3, UBN1, NKX3-1, RCOR1, NFE2, ZNF639, VDR, ZNF750, CEBPB, NR3C1, ZNF501, KMT2A, CREB1, EZH2, KLF8, FEZF1, GRHL2, MRTFA, ZHX2, SPI1, ZNF664, MIXL1, ZNF257, IRF1, GATA2, INTS13, ZNF182, ZNF146, FLI1, MXI1, MRTFB, NFYB, MYF5, RUNX1, ZNF585A, SMC1A, BCL6, CEBPA, EZH2phosphoT487, CRY1, ZNF335, AFF4, POU4F2, SIN3A, SOX13, SMAD3, ZFP37, ZNF770, ERG3, SMARCC1, PRDM10, ZBTB2, ZNF384, ZNF35, NOTCH1, RUNX2, ZSCAN30, CDK6, OSR2, ZNF184, GATA4, SP3, NRF1, ARNT, PBX4, BACH1, DAXX, TFDP1, ZEB2, FOXM1, MAFB, PBX3, FOS, CDK8, CHD1, ZNF10, MED1, CSNK2A1, ZEB1, PML, ZNF558, MYB, SCRT2, PIAS1, ZMYM3, TEAD3, ZNF3, KLF9, NCOA1, L3MBTL2, EVI1, TBX5, MAFK, SP1, TFAP2A, BCL11A, NR4A1, HNF4A, REST, ZBTB7A, ZHX1, POU2F3, ASH2L, CTBP2, PHIP, TCF3, FOXP1, PRDM6, SMC3, ELL2, ZNF34, MLLT1, STAG2, CXXC4, ZNF394, SKI, NELFA, ZNF283, STAG1, FOXA2, MTA3, CREM, CHD2, SS18, NFATC1, EBF1, ZNF692, GTF2B, MAFF, WT1, ZSCAN16, FOXF1, MEF2C, CDK9, ZNF580, HOXB13, KDM1A, ZNF19, YY1, RELA, TARDBP, NEUROD1, JUNB, BRG1, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, GATA1, ZNF143, TLE3, KLF4, BCL11B, SP7, NCOA3, NR2F2, TCF7L2, KDM5B, TP53, PKNOX1, MED, ZSCAN22, MYOD1, PHOX2B, T, ELF3, BRD2, AR, TAF1, ZBTB16, RXR, ZNF324, EGLN2, ZNF366, EGR1, ZNF280D, ZBTB42, JUND, BRD4, SCRT1, CLOCK, MAZ, ZNF440, BRCA1, FOSL2

Target gene symbol (double-evidenced CRMs): USP25,NRIP1,HSPA13

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 25

Related genes and loops

Related gene: ENSG00000155304, ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413676