- Basic information
- CohesinDB ID: CDBP00413708
- Locus: chr21-16278935-16281446
-
Data sourse: ENCSR230ZWH, GSE131956, GSE126634, GSE152721, ENCSR000ECE, GSE62063, GSE206145-NatGen2015, ENCSR198ZYJ, GSE130135, GSE116344, GSE165895
-
Cell type: H1-hESC, Fibroblast, RH4, HEK293T, Neurons-H1, Ramos, GBM39, Liver, HAP1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: NIPBL,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 39%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: ZNF468, FOXO1, PGR, SOX2, NME2, XBP1, FOXA1, CHD7, PRDM1, ZSCAN4, HDAC3, SFPQ, TEAD1, ETV1, ESR1, CTCF, BAF155, PRDM4, E2F1, TEAD4, PDX1, RBPJ, NANOG, CHD8, POU2F2, BRD3, POU5F1, ZNF317, STAT1, ERG, ONECUT1, MYC, SMARCA4, RAD21, TOP1, GRHL3, RXRA, GABPA, STAT3, NKX3-1, VDR, NR3C1, CEBPB, CREB1, GATA2, MRTFB, RUNX1, ZFX, POU4F2, SMARCC1, CREBBP, ZNF384, NOTCH1, RUNX2, GATA4, ARNT, CHD1, CDK8, FOS, MED1, CSNK2A1, CEBPD, PIAS1, KLF9, NUP98-HOXA9, MAFK, HNF4A, POU2F3, ASH2L, HOXA9, PHIP, FOXP1, PRDM6, FOXA2, SS18, GTF2B, HOXB13, YY1, RELA, NEUROD1, BRG1, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, TLE3, NCOA3, NR2F2, TP53, PHOX2B, BRD2, AR, TAF1, EGLN2, NOTCH3, BRD4, BRCA1, AHR
- Target gene symbol (double-evidenced CRMs): NRIP1,USP25
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 10
- Related genes and loops
- Related gene:
ENSG00000180530,
ENSG00000155313,
- Related loop:
chr21:15000000-15025000~~chr21:16275000-16300000,
chr21:15875000-15900000~~chr21:16275000-16300000,
chr21:15893541-15896042~~chr21:16279284-16280943,
chr21:15900000-15925000~~chr21:16275000-16300000,
chr21:16050000-16075000~~chr21:16275000-16300000,
chr21:16075000-16100000~~chr21:16275000-16300000,
chr21:16100000-16125000~~chr21:16275000-16300000,
chr21:16175000-16200000~~chr21:16275000-16300000,
chr21:16275000-16300000~~chr21:16400000-16425000,
chr21:16275000-16300000~~chr21:17250000-17275000,