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Basic information

CohesinDB ID: CDBP00413711

Locus: chr21-16284608-16285086

Data sourse: GSE62063, GSE120943, GSE98367

Cell type: Monocytes, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: NIPBL,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 40% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 61%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF468, FOXO1, PGR, SOX2, NME2, XBP1, FOXA1, CHD7, PRDM1, ZSCAN4, HDAC3, SFPQ, TEAD1, ETV1, ESR1, CTCF, BAF155, PRDM4, E2F1, TEAD4, PDX1, RBPJ, NANOG, CHD8, POU2F2, BRD3, POU5F1, ZNF317, STAT1, ERG, ONECUT1, MYC, SMARCA4, RAD21, TOP1, GRHL3, RXRA, GABPA, STAT3, NKX3-1, VDR, NR3C1, CEBPB, CREB1, GATA2, MRTFB, RUNX1, ZFX, POU4F2, SMARCC1, CREBBP, ZNF384, NOTCH1, RUNX2, GATA4, ARNT, CHD1, CDK8, FOS, MED1, CSNK2A1, CEBPD, PIAS1, KLF9, NUP98-HOXA9, MAFK, HNF4A, POU2F3, ASH2L, HOXA9, PHIP, FOXP1, PRDM6, FOXA2, SS18, GTF2B, HOXB13, YY1, RELA, NEUROD1, BRG1, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, TLE3, NCOA3, NR2F2, TP53, PHOX2B, BRD2, AR, TAF1, EGLN2, NOTCH3, BRD4, BRCA1, AHR

Target gene symbol (double-evidenced CRMs): USP25,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413711