- Basic information
- CohesinDB ID: CDBP00413756
- Locus: chr21-16453682-16455230
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE126634, ENCSR760NPX, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE103477, GSE25021, ENCSR330ELC, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000EAC, ENCSR000BKV, GSE115250, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE152721, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE138105, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR807WAC, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE206145, ENCSR981FDC, GSE126990, GSE50893, ENCSR000ECS
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Cell type: SLK, Liver, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, H1-hESC, GM12878, GM2588, SK-N-SH, HeLa-Tet-On, THP-1, HUES64, MCF-7, Hela-Kyoto, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, HeLa, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 41% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.622
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 74%,
"7_Enh": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, POU2F2, SMC1A, PPARG, FOXA2, CHD8, ZNF660, PGR, SS18, SOX2, STAG2, POU4F2, GTF2B, SMAD3, FOXA1, SRF, ZNF654, ZBTB33, SUZ12, HOXB13, SMARCC1, HNRNPK, YY1, ERG, ZBTB2, ZNF384, ASCL1, KDM1A, RELA, AHR, ONECUT1, NEUROD1, SMARCA4, CTCFL, RAD21, CHD7, RXRA, OTX2, GATA3, STAT3, MED1, SFPQ, CSNK2A1, TLE3, GFI1B, TEAD1, KDM5B, ESR1, KLF9, FEZF1, ZNF334, USF2, MYOD1, PHOX2B, ELF3, CTCF, JUN, SP1, BCL11A, BAF155, HNF4A, AR, SPI1, SND1, EP300, TAF1, GATA2, REST, POU2F3, RAD51, HOXA9, CTBP2, BRD4, FOXP1, SMC1, ZNF440, SMC3, MYF5, BRCA1, STAG1, RBPJ
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
- Related loop:
chr21:16075000-16100000~~chr21:16450000-16475000,
chr21:16325000-16350000~~chr21:16425000-16450000,
chr21:16425000-16450000~~chr21:17250000-17275000,
chr21:16450000-16475000~~chr21:16550000-16575000,
chr21:16450000-16475000~~chr21:16575000-16600000,
chr21:16450000-16475000~~chr21:16600000-16625000,
chr21:16450000-16475000~~chr21:16850000-16875000,
chr21:16450000-16475000~~chr21:16925000-16950000,
chr21:16450000-16475000~~chr21:17025000-17050000,
chr21:16450000-16475000~~chr21:17125000-17150000,
chr21:16450000-16475000~~chr21:17250000-17275000,
chr21:16453706-16455321~~chr21:16607527-16609497,
chr21:16453720-16456792~~chr21:17269429-17272265,
chr21:16453732-16455413~~chr21:17044535-17046501,
chr21:16453732-16455413~~chr21:17269224-17271500,
chr21:16453738-16455573~~chr21:16607762-16609529,
chr21:16453760-16455329~~chr21:16607672-16609536,
chr21:16453763-16456291~~chr21:16572937-16574492,
chr21:16453763-16456291~~chr21:17044592-17046378,
chr21:16453967-16455273~~chr21:16607552-16609634,