- Basic information
- CohesinDB ID: CDBP00413778
- Locus: chr21-16536082-16538207
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Data sourse: GSE131956, GSE138405, GSE126634, ENCSR000BLY, GSE206145, GSE62063, ENCSR000EDE, ENCSR000EHX, GSE138105, GSE126990, GSE108869, ENCSR000ECS, ENCSR917QNE
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Cell type: RPE, Hela-Kyoto, SLK, HeLa-S3, GBM39, SK-N-SH, Liver, HAP1, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: NIPBL,SA1,Rad21,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 41%,
"1_TssA": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF660, SOX2, XBP1, PATZ1, FOXA1, ZFHX2, ATF3, NFIC, ZNF362, ZBTB44, PRDM1, RUNX3, MORC2, ZNF189, ZSCAN4, MITF, SFPQ, ZNF629, TEAD1, KLF6, NFE2L2, ESR1, OCA2, MED26, PITX3, USF2, JUN, CTCF, TCF12, EP300, BAF155, RFX5, E2F1, TEAD4, GTF2F1, RBPJ, EED, POU2F2, CHD8, BRD3, ZNF263, TOP2A, MYCN, ZSCAN21, ZBTB17, ZBTB48, DUX4, STAT1, SRF, HIC1, TBP, ERG, ZBTB21, HOXC5, ETS1, MYC, ONECUT1, SMARCA4, ZKSCAN2, RFX1, RAD21, TOP1, GRHL3, RXRA, NKX2-1, STAT3, UBN1, NKX3-1, NFE2, RCOR1, ZNF639, ARNTL, NR3C1, CEBPB, ZNF750, CREB1, EZH2, KLF8, GRHL2, EBF3, ZHX2, SPI1, GATA2, ZNF182, FLI1, MXI1, MRTFB, MYF5, RUNX1, SMC1A, CEBPA, NKX2-2, SIN3A, AFF4, POU4F2, ZNF335, ZFP37, ERG3, TWIST1, SMARCC1, PRDM10, ZNF384, ZNF35, RUNX2, ZNF184, NRF1, BACH1, ARNT, NFIB, PBX4, ATF2, ZNF518A, FOXM1, PBX3, SP2, CHD1, CDK8, FOS, MED1, CSNK2A1, ZEB1, CEBPD, ZXDB, PIAS1, KLF9, NUP98-HOXA9, MAFK, SP1, USF1, BCL11A, HNF4A, REST, ZNF479, ZHX1, POU2F3, ASH2L, CTBP2, PHIP, FOXP1, PRDM6, SMC3, ELL2, ZNF394, PPARG, FOXA2, EBF1, CHD2, SS18, ZNF600, ZNF692, MAFF, WT1, ZBTB33, HOXB13, KDM1A, YY1, RELA, NEUROD1, JUNB, BRG1, ISL1, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, HAND2, TLE3, KLF4, SP7, NCOA3, NR2F2, NEUROG2, TP53, ZBTB6, NFKB1, MYOD1, ZSCAN22, PHOX2B, BRD2, ARRB1, AR, PAX3-FOXO1, TAF1, ZNF324, EGLN2, ZNF366, ZNF280D, MYNN, NOTCH3, BRD4, JUND, MAZ, ZSCAN23, BRCA1, ZNF316
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 16
- Related genes and loops