- Basic information
- CohesinDB ID: CDBP00413949
- Locus: chr21-17456778-17457458
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Data sourse: GSE62063, GSE67783, GSE86191
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Cell type: HCT-116, HSPC, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: NIPBL,SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
47% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 82%,
"5_TxWk": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, KDM3A, THAP1, ZBTB44, IKZF3, SFPQ, TEAD1, ZNF121, OCA2, PITX3, ZNF561, ZNF577, SOX5, PAX8, ZNF407, E2F4, ZNF528, RFX3, GATAD2A, NANOG, BRD3, POU5F1, ZNF263, CTBP1, DUX4, STAT1, SAP130, ERG, ZBTB21, EZH1, SMARCA4, TOP1, FOXK2, UBN1, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RUVBL2, RUNX1, CEBPA, NKX2-2, HDAC1, SP5, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, SATB1, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, CBFA2T2, CBX3, ZNF225, CREM, CHD2, NFATC1, SS18, BRF2, ZSCAN16, WT1, MEF2C, MPHOSPH8, DEAF1, JUNB, NEUROD1, ZFP36, BATF, KLF4, BCL11B, ZBTB6, MED, BCL6B, EGR2, ELF3, ARID4B, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, HNF1A, ZNF101, KDM4B, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZC3H8, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, MITF, ZNF467, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, DPF2, RYBP, SIX5, IRF4, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF317, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, NBN, CHD4, ONECUT1, TSHZ1, ZNF2, HOMEZ, FOXP2, KDM4A, RXRA, NKX3-1, MIER3, HNRNPH1, NR3C1, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, ZBTB24, LDB1, AFF4, SOX13, POU4F2, ZFP3, ZNF770, ZNF513, ZNF18, SP3, ARNT, ZNF48, PRDM9, HMBOX1, ZEB2, PBX3, MAFB, ZNF10, ETV6, HMGXB4, NCAPH2, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, STAG1, ZNF394, TRP47, MTA3, MEIS1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF222, BRG1, ISL1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, TERT, TP53, NFKB1, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, BDP1, SOX2, PATZ1, UBTF, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, MZF1, KLF6, NFE2L2, ZNF217, ESR1, ZNF695, ZNF260, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZBTB1, ZSCAN5A, HIC1, SP4, ERG2, TBP, HNF4G, OGG1, ETS1, MYC, ARID1B, PHF21A, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, INO80, EZH2, ZNF652, MRTFA, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, MYBL2, CREBBP, ZNF384, ZNF35, RARA, NFYC, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, SUPT16H, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HOXA9, HNRNPLL, BCOR, FOXP1, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, FOXO3, RELA, TARDBP, SKIL, MAX, ZNF223, ZNF592, GFI1B, NEUROG2, TCF7L2, KDM5B, PKNOX1, AR, ZNF324, ZNF280D, DMAP1, AHR, FOSL2, ZNF391, HMG20A, LCORL, ZSCAN5C, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, NFIC, ZNF362, PRDM1, KLF14, ZNF629, TRIM28, BCLAF1, ETV1, RCOR2, USF2, MBD4, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, CHD8, MYCN, ID3, GATAD1, ARID3A, ZNF585B, ASCL1, USP7, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF501, ZNF750, FEZF1, TRPS1, ZNF664, EHF, HBP1, IRF1, TFE3, GTF3C5, SREBF1, ZGPAT, MRTFB, ATF1, SMC1A, CBX1, ZNF335, ZFX, SMAD3, PCBP2, CBX8, TWIST1, IRF2, PRPF4, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, PBX4, NRF1, FOS, CHD1, TGIF2, MED1, CEBPD, ZNF558, SCRT2, MYB, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, RBBP5, MIER2, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NR2F2, ZNF512, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, BRF1, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 1
- Related genes and loops