- Basic information
- CohesinDB ID: CDBP00413952
- Locus: chr21-17460821-17464200
-
Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR000BLY, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, ENCSR000EEG, ENCSR338DUC, ENCSR768DOX, ENCSR000BLS, GSE206145, ENCSR981FDC, ENCSR247LSH, GSE105004, ENCSR167MTG, GSE131956, ENCSR000HPG, ENCSR335RKQ, ENCSR054FKH, GSE68388, GSE126990, ENCSR748MVX, GSE73207
-
Cell type: RPE, Fibroblast, Hela-Kyoto, HEK293T, Hep-G2, TF-1, A-549, HCAEC, HeLa, GBM39, IMR-90, SK-N-SH, Liver, HAP1, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
47% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 44%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, ZNF660, HNF1A, FOXA1, RBFOX2, RXRB, ZFHX2, KDM3A, TFAP4, HNRNPK, SIN3B, TSC22D4, ATF3, NFIC, THRB, ZFP64, ZNF362, ZBTB44, PRDM1, MXD4, ZNF189, TP63, HDAC3, CDX2, KLF5, TEAD1, ELF1, KLF6, ETV1, NFE2L2, KLF10, RCOR2, ESR1, HNF1B, TP73, USF2, JUN, TCF12, CTCF, EP300, BAF155, L3MBTL4, MNT, SOX5, GATA6, TRIM24, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, PDX1, RBPJ, MLX, TFAP2C, GLIS1, POU2F2, BRD3, MYCN, POU5F1, ZSCAN21, ZBTB17, DUX4, ZBTB48, ERF, STAT1, GATAD1, SAP130, GMEB2, HIC1, ARID3A, ERG2, TBP, HNF4G, ERG, CHD4, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, MCRS1, STAT3, ZNF614, XRCC5, NKX3-1, RCOR1, MIER3, NR2F6, NFE2, ARNTL, VDR, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, TBL1XR1, ZNF652, EBF3, GABPB1, ZHX2, SPI1, MIXL1, TFE3, IRF1, HDAC2, SSRP1, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, MXI1, ZNF766, MRTFB, NFIL3, ETV5, RUNX1, THAP11, CTNNB1, BCL6, ZBTB24, CEBPA, NKX2-2, LDB1, SMC1A, SOX13, SIN3A, CBX1, SMAD3, ZFP37, ERG3, SP5, SMARCC1, TWIST1, MEF2A, MYBL2, RARA, ZNF384, NFYC, CREBBP, PRPF4, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, ARNT, BACH1, ZNF48, SMAD4, HMBOX1, PBX3, CBFA2T3, ZNF10, FOS, CDK8, SMARCB1, HMGXB4, MED1, ZEB1, TEAD3, MYB, ZNF680, PIAS1, ZMYM3, SUPT16H, NCOA1, TBX5, MAFK, SP1, USF1, NIPBL, HNF4A, BCL11A, IKZF5, REST, ASH2L, PHIP, FOXP1, SMC3, NCOR2, ETV4, ZNF394, SKI, PPARG, FOXA2, CREM, MIER2, WT1, MEF2C, ZBTB33, TCF7, CDK9, ZNF580, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, NEUROD1, JUNB, AHR, BRG1, TCF4, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, CEBPG, KLF4, SP7, GFI1B, NR2F2, NEUROG2, TP53, NFKB1, EGR2, BRD2, ELF3, KAT8, PHF5A, BHLHE40, AR, ARID4B, TAF1, NFKBIZ, ZBTB40, RXR, ZNF366, EGR1, ZBTB26, NCOR1, BRD4, JUND, CUX1, MAZ, ZSCAN23, ZNF24, DMAP1, FOSL2
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 8
- Related genes and loops