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Basic information

CohesinDB ID: CDBP00414217

Locus: chr21-18951080-18952628

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE126634, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000BTU, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR000EEG, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE131956, GSE129526, GSE111913, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, K-562, GM18486, DKO, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, THP-1, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, HUVEC, GM19238, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 26% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.489

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 30% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 80%, "9_Het": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: CBX5, ZNF660, SOX2, XBP1, FOXA1, CTCFL, ELF1, TRIM28, TEAD1, ETV1, NFE2L2, ESR1, CTCF, JUN, E2F6, IRF4, E2F1, SMC1, POU2F2, CHD8, BRD3, POU5F1, MYCN, CTBP1, DUX4, SRF, ERG, HOXC5, MYC, SMARCA4, RAD21, PROX1, NKX2-1, GABPA, IKZF1, NR3C1, CEBPB, ZBTB11, EBF3, GABPB1, SPI1, IRF1, GATA2, SMARCA5, ATF1, RUNX1, SMC1A, CBX1, CEBPA, NKX2-2, SIN3A, ZFX, SMAD3, ZNF654, TRIM22, SMARCC1, ZBTB2, NRF1, ARNT, PBX4, FOXM1, MED1, SCRT2, L3MBTL2, BCL11A, REST, SMC3, STAG2, STAG1, EBF1, WT1, CDK9, HOXB13, KDM1A, YY1, RELA, HIF1A, GATA3, MAX, ZNF143, HAND2, CEBPG, KDM5B, TP53, PHOX2B, AR, PAX3-FOXO1, ZBTB40, EGLN2, EGR1, NOTCH3, BRD4

Target gene symbol (double-evidenced CRMs): .

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 18

Related genes and loops

Related gene:

eachgene

Deatailed information for cohesin site CDBP00414217