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Basic information

CohesinDB ID: CDBP00414305

Locus: chr21-19607944-19609050

Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE126634, ENCSR000BLY, GSE105028, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000BTU, GSE138405, GSE76893, GSE152721, GSE116344, ENCSR703TNG, GSE145327, ENCSR000ECE, GSE62063, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, ENCSR000EDE, GSE83726, GSE50893, GSE73207

Cell type: MCF-7, H1-hESC, Hela-Kyoto, RH4, THP-1, TF-1, Ishikawa, Ramos, GM2588, HeLa-S3, HUES64, SK-N-SH, Liver, OCI-AML-3, HAP1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.822

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 26% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 74%, "7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, MEIS2, FOXA1, PBX2, BMI1, ATF3, SMARCE1, TRIM28, LMO2, ESR1, CTCF, TCF12, EP300, GATA6, DPF2, TRIM24, SOX6, TEAD4, PDX1, NANOG, TOP2A, CTBP1, STAT1, ERG, HOXC5, ASCL1, MYC, SMARCA4, RFX1, ARID1B, RAD21, GRHL3, GABPA, STAT3, RCOR1, ESRRA, CEBPB, SPI1, GATA2, MXI1, HEXIM1-CDK9, RUNX1, SMC1A, HDAC1, LDB1, SIN3A, TWIST1, ARNT, PBX4, HMBOX1, CBFA2T3, MAFB, FOXJ2, CDK8, CEBPD, SMAD1, C11orf30, STAT5A, BCL11A, ZBTB7A, SMC3, STAG1, FOXA2, CBX3, MEF2C, RELA, NEUROD1, CHAMP1, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, HAND2, TCF7L2, KDM5B, PKNOX1, PHOX2B, AR, PAX3-FOXO1, ZBTB16, EGLN2, HSF1, BRD4, ZNF316

Target gene symbol (double-evidenced CRMs): .

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene:

eachgene

Deatailed information for cohesin site CDBP00414305