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Basic information

CohesinDB ID: CDBP00414487

Locus: chr21-21027981-21029993

Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE76893, GSE62063, ENCSR703TNG, GSE25021

Cell type: MCF-7, HCT-116, HSPC, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: NIPBL,SA1,Rad21,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 27% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 71%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, PGR, SOX2, MEIS2, FOXA1, PBX2, MEN1, NFIC, CHD7, JMJD1C, TEAD1, TRIM28, ZNF217, ESR1, TP73, CTCF, TCF12, JUN, EP300, BAF155, DPF2, TRIM24, TEAD4, KMT2B, RBPJ, TFAP2C, NANOG, POU5F1, RUNX1T1, CTBP1, ZBTB48, ZNF205, MLLT3, HOXC5, ERG, MYC, SMARCA4, RAD21, GRHL3, GABPA, STAT3, IKZF1, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, GRHL2, TRPS1, SPI1, KDM5A, HDAC2, GATA2, FLI1, NCOA2, RUNX1, CBX1, CEBPA, SIN3A, ZFX, POU4F2, SMARCC1, CREBBP, ZXDC, RUNX2, GR, ARNT, DAXX, PBX4, ZEB2, HMBOX1, FOXM1, FOS, CDK8, MED1, MYB, PIAS1, SMAD1, STAT5A, NIPBL, BCL11A, NR4A1, CTBP2, MBD2, TCF3, MLLT1, SKI, ZNF283, GTF2B, MEF2C, ZNF823, CDK9, HOXB13, RELA, JUNB, SP140, HIF1A, OTX2, GATA3, NRIP1, TLE3, CEBPG, NCOA3, KDM5B, TP53, PHOX2B, AR, EGLN2, BRD4, JUND, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): NCAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 28

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154654,

eachgene

Deatailed information for cohesin site CDBP00414487