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Basic information

CohesinDB ID: CDBP00414515

Locus: chr21-21162657-21165885

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, GSE115248, GSE105004, GSE155324, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, TC-71, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 56% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.244

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 27% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 66%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, MEIS2, XBP1, FOXA1, PBX2, HDGF, ATF3, SFPQ, NFE2L2, ESR1, CTCF, TCF12, EP300, BAF155, DPF2, IRF4, SMC1, TEAD4, PDX1, NANOG, TOP2A, STAT1, SRF, NBN, ARID3A, ERG, HOXC5, ONECUT1, MYC, SMARCA4, ARID1B, RAD21, GABPA, XRCC5, NKX3-1, IKZF1, RCOR1, NFE2, DACH1, CEBPB, STAT5B, KMT2A, SPI1, MIXL1, HDAC2, GATA2, ZSCAN29, ZNF777, FLI1, SMC1A, CBX1, HDAC1, NKX2-2, TRIM22, ZBTB2, ZNF384, ARNT, ZEB2, SUPT5H, CDK8, MED1, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, BCL11A, NR4A1, REST, ZNF479, FOXP1, SMC3, STAG1, MLLT1, STAG2, FOXA2, CBX3, GTF2B, ZBTB33, MEF2C, CDK9, HOXB13, ZNF19, RELA, YY1, CHAMP1, HIF1A, GATA3, BATF, MAX, SPIB, GATA1, ZNF143, TLE3, ZNF592, GFI1B, KDM5B, PKNOX1, PHOX2B, AR, ZBTB40, RXR, EGLN2, HSF1, BRD4, JUND, ZNF24, ZNF316

Target gene symbol (double-evidenced CRMs): NCAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 47

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154654,

eachgene

Deatailed information for cohesin site CDBP00414515