- Basic information
- CohesinDB ID: CDBP00414537
- Locus: chr21-21238208-21240548
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Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE72082, GSE138405, GSE76893, ENCSR000BLY, ENCSR000EDE, ENCSR703TNG, GSE25021, GSE115602
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Cell type: MCF-7, HeLa-S3, Hela-Kyoto, SK-N-SH
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
27% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 94%,
"9_Het": 2%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, PGR, FOXA1, MEN1, WDHD1, SMARCE1, TEAD1, ETV1, ZNF217, ESR1, JUN, TCF12, CTCF, EP300, BAF155, GATA6, DPF2, RFX5, RAD51, E2F1, NR5A2, TEAD4, TFAP2C, NANOG, MYCN, CTBP1, STAT1, SRF, HNF4G, ERG, MYC, RAD21, STAT3, NKX3-1, RCOR1, VDR, NR3C1, ESRRA, CEBPB, CREB1, ZBTB11, GRHL2, EBF3, TRPS1, ZHX2, ZSCAN2, KDM5A, HDAC2, GATA2, GATAD2B, NCOA2, RUNX1, SMC1A, CBX1, CEBPA, SIN3A, TWIST1, ZXDC, CREBBP, RUNX2, GATA4, GR, NFIB, ARNT, PBX4, FOXM1, CHD1, FOS, MED1, PML, PIAS1, ZMYM3, NCOA1, STAT5A, MAFK, NIPBL, USF1, TFAP2A, ARID1A, ZHX1, ATF7, CTBP2, MBD2, STAG1, MAFF, HOXB13, YY1, RELA, TARDBP, NEUROD1, BRG1, ISL1, HIF1A, GATA3, MAX, NRIP1, ZNF143, MTA1, HAND2, TLE3, CEBPG, NCOA3, NR2F2, TCF7L2, NR2F1, TP53, PHOX2B, AR, TAF1, ZNF579, YAP1, EGLN2, MAML3, HSF1, BRD4, JUND, CUX1, MAZ, TBX2, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): NCAM2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 31
- Number of somatic mutations (non-coding): 9
- Related genes and loops
- Related gene:
ENSG00000154654,
- Related loop:
chr21:21225000-21250000~~chr21:21350000-21375000,
chr21:21225000-21250000~~chr21:21450000-21475000,
chr21:21225000-21250000~~chr21:21475000-21500000,
chr21:21225000-21250000~~chr21:21500000-21525000,
chr21:21225000-21250000~~chr21:21600000-21625000,
chr21:21225000-21250000~~chr21:21675000-21700000,
chr21:21225000-21250000~~chr21:21900000-21925000,
chr21:21225000-21250000~~chr21:22100000-22125000,
chr21:21225000-21250000~~chr21:22525000-22550000,
chr21:21225000-21250000~~chr21:22775000-22800000,
chr21:21225000-21250000~~chr21:22875000-22900000,
chr21:21225000-21250000~~chr21:23375000-23400000,
chr21:21231430-21233404~~chr21:21920936-21923160,
chr21:21231477-21233381~~chr21:21687907-21690091,
chr21:21231521-21233402~~chr21:21687901-21690144,
chr21:21231535-21233401~~chr21:21687936-21689865,
chr21:21231535-21233401~~chr21:21920963-21923078,
chr21:21231535-21233410~~chr21:21920932-21923125,
chr21:21231541-21233362~~chr21:21920929-21923014,
chr21:21231560-21233379~~chr21:21687926-21689834,
chr21:21231560-21233379~~chr21:21920967-21923026,
chr21:21231567-21233381~~chr21:21921006-21922867,
chr21:21231594-21233378~~chr21:21688096-21689849,
chr21:21231694-21233389~~chr21:21687914-21690120,
chr21:21231694-21233389~~chr21:21920950-21923088,
chr21:21231867-21233358~~chr21:21688020-21689825,
chr21:21231867-21233358~~chr21:21921063-21923124,