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Basic information

CohesinDB ID: CDBP00414540

Locus: chr21-21247060-21248771

Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE138405, GSE111913, GSE76893, GSE206145-NatGen2015, GSE62063, ENCSR703TNG, GSE126990, GSE115602

Cell type: MCF-7, Hela-Kyoto, Fibroblast, RT-112, HSPC, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 27% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 92%, "9_Het": 3%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, FOXO1, FOSL1, PGR, TOP2A, SIN3A, CTBP1, ZBTB48, SMAD3, FOXA1, ZBTB33, HOXB13, ERG, HOXC5, RELA, ZXDC, CREBBP, MEN1, JUNB, ATF3, BRG1, ARID1B, RAD21, SP140, LHX2, DAXX, ARNT, OTX2, GATA3, SMARCE1, FOXM1, STAT3, NKX3-1, FOS, IKZF1, TAL1, MED1, TLE3, NR3C1, ESRRA, SP7, CEBPB, TEAD1, CREB1, PIAS1, TCF7L2, ZNF217, ESR1, GRHL2, NFKB1, EBF3, TRPS1, JUN, TCF12, BAF155, NIPBL, EP300, BHLHE40, AR, GATA6, DPF2, GATA2, ARID1A, GATAD2B, TRIM24, RNF2, BRD4, JUND, CTBP2, FOXP1, CUX1, MBD2, MRTFB, TEAD4, TFAP2C, FOSL2

Target gene symbol (double-evidenced CRMs): NCAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 18

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154654,

eachgene

Deatailed information for cohesin site CDBP00414540