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Basic information

CohesinDB ID: CDBP00414657

Locus: chr21-21688058-21690974

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, GSE126634, GSE116868, GSE132649, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE36578, GSE76893, GSE101921, GSE135093, GSE152721, GSE51234, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE138105, GSE145327, GSE94872, GSE76815, ENCSR879KXD, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, GSE129526, ENCSR000HPG, GSE111913, GSE38411, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, HeLa-S3, IMR-90, BCBL-1, K-562, GM18486, H1-hESC, SNYDER, MB157, TC-71, GM12891, GM2588, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, GM19099, HUES64, MCF-7, T-47D, Hela-Kyoto, HCT-116, HL-60, HEK293T, MCF-10A, Neurons-H1, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, BGO3, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 34% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.456

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 24% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 91%, "9_Het": 6%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMC1A, CBX1, CHD8, POU5F1, MYCN, TEAD4, STAG2, NME2, SMAD3, FOXA1, SRF, CDK9, ERG, YY1, CREBBP, ZBTB2, RUNX2, RAD21, ARNT, HIF1A, ZNF444, MAX, ZNF143, MITF, MED1, PLAG1, CEBPB, CREB1, PIAS1, SMAD1, EZH2, ZNF217, ESR1, KDM5B, SETDB1, CTCF, USF1, SPI1, AR, PAX3-FOXO1, REST, RXR, GATA2, IRF4, HSF1, NOTCH3, BRD4, FOXP1, SMC1, MRTFB, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): NCAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 32

Related genes and loops

Related gene: ENSG00000154654,

eachgene

Deatailed information for cohesin site CDBP00414657