- Basic information
- CohesinDB ID: CDBP00414837
- Locus: chr21-22574362-22576379
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE115250, GSE138405, GSE76893, GSE101921, GSE152721, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE138105, GSE145327, GSE94872, ENCSR000EEG, GSE76815, GSE115248, ENCSR000EHW, GSE206145, ENCSR000ECE, GSE62063, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE131577
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Cell type: MDM, RH4, GM2610, SLK, Liver, TC-32, HuCC-T1, H9-hESC, GM2630, Ishikawa, Kelly, HeLa-S3, H1-hESC, SNYDER, MB157, GM2588, SK-N-SH, HeLa-Tet-On, THP-1, HUES64, MCF-7, Ramos, Hela-Kyoto, HL-60, MCF-10A, HEK293T, Hep-G2, Neurons-H1, HUVEC, HCAEC, OCI-AML-3, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 20% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.633
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
25% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 75%,
"7_Enh": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, SOX2, MEIS2, XBP1, FOXA1, PBX2, HNRNPK, CTCFL, CHD7, TRIM28, ESR1, CTCF, JUN, TCF12, EP300, IRF4, SMC1, TEAD4, PDX1, NANOG, CHD8, MYCN, POU5F1, STAT1, SRF, SP4, ERG, HOXC5, ETS1, MYC, EOMES, KDM4A, SMARCA4, RAD21, GABPA, STAT3, RCOR1, NFE2, ARNTL, KMT2A, CREB1, EBF3, FLI1, MRTFB, RUNX1, SMC1A, CBX1, CEBPA, NKX2-2, ZNF335, SMAD3, SMARCC1, TWIST1, CREBBP, ARNT, PBX4, ATF2, FOS, CDK8, CHD1, MED1, MYB, PIAS1, MAFK, BCL11A, SP1, ZBTB7A, ZNF479, ASH2L, FOXP1, SMC3, STAG2, STAG1, FOXA2, RBBP5, MEF2C, HOXB13, YY1, RELA, NEUROD1, JUNB, HIF1A, OTX2, TAL1, MAX, ZNF143, TLE3, TCF7L2, KDM5B, TP53, PKNOX1, PHOX2B, T, AR, TAF1, EGLN2, HSF1, NCOR1, BRD4, JUND, CLOCK, TBX2, AHR
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 34
- Related genes and loops