- Basic information
- CohesinDB ID: CDBP00414900
- Locus: chr21-22899910-22901504
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Data sourse: GSE105004, GSE67783, GSE86191, GSE138405, GSE206145, GSE101921, GSE62063, GSE206145-NatGen2015, ENCSR000EDE, GSE126990, GSE108869, GSE94872, ENCSR000ECS
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Cell type: RPE, Hela-Kyoto, Fibroblast, HCT-116, HUVEC, HCAEC, HeLa-S3, HeLa, HSPC, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
25% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 85%,
"9_Het": 8%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOXO1, TRP47, PGR, TOP2A, STAG2, MAFF, SMAD3, STAT1, FOXA1, ZBTB48, SMARCC1, KDM1A, PAX6, RELA, ERG, ZNF384, LYL1, JUNB, ETS1, MYC, SMARCC2, SMARCA4, ZNF90, ISL1, LHX2, PBX4, DAXX, CHD7, RAD21, OTX2, NKX2-1, SMC3, SP140, TAL1, MAX, UBN1, STAT3, FOS, CDK8, RCOR1, HAND2, ZNF92, NR3C1, CEBPB, TEAD1, CEBPD, NR2F2, KMT2A, TCF7L2, NFE2L2, LMO2, GTF3C2, USF2, EBF3, NFKB1, PHOX2B, ELF3, JUN, MAFK, EP300, TCF12, SPI1, BCL11A, AR, PAX8, REST, GATA2, ZHX1, FLI1, DEK, JUND, BRD4, SMC1, MRTFB, TEAD4, TBX2, STAG1, FOSL2
- Target gene symbol (double-evidenced CRMs): NCAM2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 25
- Related genes and loops
- Related gene:
ENSG00000154654,
- Related loop:
chr21:21225000-21250000~~chr21:22875000-22900000,
chr21:21500000-21525000~~chr21:22875000-22900000,
chr21:22175000-22200000~~chr21:22875000-22900000,
chr21:22550000-22575000~~chr21:22875000-22900000,
chr21:22625000-22650000~~chr21:22875000-22900000,
chr21:22725000-22750000~~chr21:22875000-22900000,
chr21:22875000-22900000~~chr21:22975000-23000000,
chr21:22875000-22900000~~chr21:23000000-23025000,
chr21:22875000-22900000~~chr21:23100000-23125000,
chr21:22875000-22900000~~chr21:23150000-23175000,
chr21:22875000-22900000~~chr21:23375000-23400000,
chr21:22875000-22900000~~chr21:23875000-23900000,