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Basic information

CohesinDB ID: CDBP00414961

Locus: chr21-23400845-23402059

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE126634, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, ENCSR000BKV, GSE115250, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE138105, GSE145327, GSE94872, ENCSR000EEG, GSE76815, GSE115248, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, GSE110061, GSE129526, GSE155324, ENCSR000EDE, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, Liver, TC-32, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, K-562, GM18486, GM18526, H1-hESC, SNYDER, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, MCF-7, THP-1, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 26% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.444

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 26% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 90%, "9_Het": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NANOG, SMC1A, SOX2, FOXA1, SRF, ZNF654, HOXB13, YY1, ZNF384, RAD21, TEAD1, KDM5B, STAG1, ESR1, CTCF, JUN, USF1, IRF4, POU2F3, BRD4, SMC1, MRTFB, SMC3, STAG2

Target gene symbol (double-evidenced CRMs): NCAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000154654,

eachgene

Deatailed information for cohesin site CDBP00414961