- Basic information
- CohesinDB ID: CDBP00415046
- Locus: chr21-23968077-23969817
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, GSE126634, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE73207, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE139435, ENCSR000BKV, GSE115250, GSE122299, GSE138405, GSE143937, GSE67783, GSE76893, GSE86191, GSE101921, GSE135093, GSE152721, GSE120943, ENCSR198ZYJ, GSE51234, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE138105, GSE145327, GSE93080, GSE94872, ENCSR000EEG, GSE76815, GSE206145-NatGen2015, GSE115248, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE62063, ENCSR000BMY, ENCSR000EHX, GSE206145, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, GSE38411, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, HSPC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, HUVEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 48% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.244
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
29% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 49%,
"7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, ZNF660, SOX2, MEIS2, XBP1, FOXA1, PBX2, TFAP4, LYL1, RUNX3, CBFB, MECOM, MAF, JMJD1C, INTS11, TEAD1, TRIM28, LMO2, ESR1, OCA2, CTCF, JUN, TCF12, BAF155, KLF1, LMO1, IRF4, TRIM24, DEK, SMC1, TEAD4, KMT2B, GTF2F1, PDX1, POU2F2, CHD8, BRD3, MYCN, CDK7, RUNX1T1, CTBP1, MTA2, ZBTB48, STAT1, SRF, TBP, ERG, HOXC5, PBX1, ASCL1, ONECUT1, MYC, SMARCA4, RAD21, RXRA, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, IKZF1, RCOR1, NFE2, DACH1, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, EZH2, JMJD6, SPI1, GATA2, INTS13, SIX2, FLI1, SMARCA5, RUNX1, SMC1A, CBX1, CEBPA, NKX2-2, SIN3A, ZFX, AFF4, ZNF654, TRIM22, SMARCC1, TWIST1, ZBTB2, CREBBP, NOTCH1, RARA, ARNT, DAXX, TFDP1, PBX3, CDK8, MED1, TEAD3, ZEB1, MYB, PIAS1, SMAD1, TBX5, SETDB1, EVI1, KLF16, USF1, SP1, BCL11A, HNF4A, NKX2-5, REST, ATF7, TCF3, FOXP1, SMC3, STAG2, STAG1, ZNF394, SKI, CBFA2T2, MEF2B, FOXA2, CREM, MEIS1, WT1, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, ISL1, SP140, TCF4, HIF1A, ZIC2, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, HAND2, BCL11B, GFI1B, KDM5B, PKNOX1, MED, BRD2, ELF3, T, TBX21, BHLHE40, AR, ZBTB16, HSF1, JUND, BRD4, MAZ
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
- Related loop:
chr21:21000000-21025000~~chr21:23950000-23975000,
chr21:22775000-22800000~~chr21:23950000-23975000,
chr21:23125000-23150000~~chr21:23950000-23975000,
chr21:23130480-23132090~~chr21:23967883-23969794,
chr21:23130622-23132031~~chr21:23967933-23969495,
chr21:23400000-23425000~~chr21:23950000-23975000,
chr21:23725000-23750000~~chr21:23950000-23975000,
chr21:23850000-23875000~~chr21:23950000-23975000,
chr21:23853101-23855059~~chr21:23967784-23969703,
chr21:23853126-23855655~~chr21:23967674-23970175,
chr21:23853141-23855184~~chr21:23967552-23970117,
chr21:23853150-23855185~~chr21:23967090-23970155,
chr21:23853165-23855136~~chr21:23967703-23969775,
chr21:23853200-23855526~~chr21:23967713-23970278,
chr21:23853226-23854721~~chr21:23968041-23969577,
chr21:23853333-23855128~~chr21:23967836-23970190,
chr21:23853384-23854703~~chr21:23967950-23969661,
chr21:23853400-23854672~~chr21:23967763-23970160,
chr21:23853410-23854705~~chr21:23968015-23969702,
chr21:23935462-23937462~~chr21:23967552-23970117,
chr21:23967674-23970175~~chr21:24513395-24515016,
chr21:23968015-23969702~~chr21:24045310-24046693,