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Basic information

CohesinDB ID: CDBP00415211

Locus: chr21-25368696-25371342

Data sourse: ENCSR000EFJ, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR000EHX, GSE68388, GSE138105, GSE108869, ENCSR000ECS, GSE165895

Cell type: RPE, Fibroblast, SLK, HeLa-S3, IMR-90, SK-N-SH, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 35% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 60%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GATA2, EP300, MYCN, ISL1, PRDM1, ESR1, BRD4, PITX3, GATA3, FOXA1, SETDB1, EBF3, PHOX2B, TWIST1, RCOR1, KDM1A, HAND2

Target gene symbol (double-evidenced CRMs): APP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415211