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Basic information

CohesinDB ID: CDBP00415261

Locus: chr21-25570886-25571971

Data sourse: ENCSR000DZP, GSE206145, ENCSR000BMY, GSE103477, GSE50893

Cell type: MDM, GM12878, GM12891, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SMC3,Rad21,SA1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 61% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 66%, "15_Quies": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, HDGF, MEN1, SRSF7, MORC2, PAX5, TEAD1, LMO2, OCA2, ARID5B, PAX8, ZNF528, KMT2B, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ERF, STAT1, ERG, PAX6, ZNF597, NFKB2, SMARCA4, RFX1, RCOR1, CD74, DACH1, CEBPB, CREB1, EPAS1, BMPR1A, ZHX2, MIXL1, GATA2, SIX2, FLI1, HCFC1, DRAP1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, TRIM22, SMARCC1, PRDM10, ZBTB2, SOX11, TFDP1, ATF2, FOXM1, PML, TERF1, PIAS1, SMAD1, EVI1, STAT5A, GSPT2, ARID2, NFATC3, MEF2B, ZNF207, CREM, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, MAF1, SPIB, KLF4, BCL11B, MED, EGR2, ELF3, RXR, ZNF366, HSF1, NCOR1, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, HNF1A, PBX2, HNRNPK, TSC22D4, THRB, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, BACH2, JMJD1C, MAF, INTS11, ELF1, SNAI2, SMAD5, CTCF, JUN, MNT, LMO1, RYBP, DPF2, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MTA2, ZSCAN21, ZBTB48, ZBTB17, ZNF317, SRF, DDX5, NBN, PBX1, KDM4A, HOMEZ, FOXP2, LHX2, RXRA, BATF3, NKX3-1, PRDM14, VDR, NR3C1, ESRRA, STAT5B, KMT2A, KLF8, GRHL2, EBF3, SMARCA5, EZH2phosphoT487, AFF4, POU4F2, ZNF18, CEBPZ, ARNT, BACH1, PRDM9, HMBOX1, ZEB2, ETV6, PBX3, NCAPH2, KLF9, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, PRDM6, SMC3, STAT2, MLLT1, STAG2, STAG1, ZNF394, TRP47, MTA3, EBF1, MEIS1, MAFF, BCL3, KDM1A, BRG1, ISL1, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, CBX5, PGR, ZNF496, SOX2, LEO1, RING1B, TFAP4, BMI1, CHD7, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SND1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, HIC1, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, MRTFA, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, ZNF384, ZNF35, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, MAFK, NR4A1, HNF4A, REST, ARID1A, HOXA9, BCOR, FOXP1, AATF, NCOR2, HDAC6, GTF2B, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, AHR, FOSL2, E2F7, MEIS2, SUZ12, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, HDAC3, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, MLL, HNF1B, USF2, TCF12, EP300, BAF155, SOX6, RAD51, E2F1, SMC1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, MLLT3, ARID3A, RAD21, GRHL3, PROX1, NFE2, ZNF639, ZNF664, IRF1, MRTFB, SMC1A, MAFG, SIRT6, ZFX, ZNF534, SMAD3, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, KDM6B, SCRT2, SETDB1, HIF2A, NIPBL, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, E2F8, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, BHLHE22, GATA1, HAND2, TLE3, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, TAF1, ZBTB40, NOTCH3, MAZ, ZNF440, ZNF24

Target gene symbol (double-evidenced CRMs): .

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene:

eachgene

Deatailed information for cohesin site CDBP00415261