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Basic information

CohesinDB ID: CDBP00415338

Locus: chr21-25903499-25904624

Data sourse: GSE98367, ENCSR000BLY, GSE206145-NatGen2015, GSE62063, ENCSR000BMY, GSE83726, GSE116344

Cell type: Fibroblast, RH4, GM12878, SK-N-SH, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: NIPBL,Rad21,Mau2,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 48%, "4_Tx": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MEIS2, XBP1, FOXA1, PBX2, BMI1, NFIC, ZNF362, RUNX3, MECOM, PAX5, JMJD1C, TRIM28, ZNF217, ESR1, LMO2, TP73, CTCF, TCF12, EP300, DPF2, IRF4, TRIM24, TEAD4, KMT2B, TFAP2C, EED, RBPJ, POU2F2, MYCN, RUNX1T1, MTA2, STAT1, NBN, ERG, MYC, RAD21, GRHL3, NKX2-1, STAT3, IKZF1, ESRRA, KMT2A, EZH2, GRHL2, SPI1, INTS13, GATAD2B, SIX2, FLI1, SMARCA5, RELB, MRTFB, RUNX1, SMC1A, ZFX, TRIM22, ZNF384, ARNT, BACH1, ATF2, PBX3, FOXM1, FOS, CDK8, MED1, MYB, EVI1, STAT5A, RBM22, BCL11A, REST, ATF7, HOXA9, NFATC3, MEF2B, CREM, MEIS1, EBF1, MEF2C, CDK9, YY1, RELA, TARDBP, JUNB, TCF4, SKIL, HIF1A, GATA3, BATF, TAL1, MAX, SPIB, ZNF592, NR2F1, PKNOX1, MED, MYOD1, TBX21, BHLHE40, AR, NCOR1, IKZF2, BRD4, JUND, NOTCH3, ZNF24

Target gene symbol (double-evidenced CRMs): APP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415338