- Basic information
- CohesinDB ID: CDBP00415340
- Locus: chr21-25911994-25912826
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Data sourse: GSE67783, ENCSR230ZWH, GSE86191, GSE101921, GSE68388, ENCSR917QNE
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Cell type: HCT-116, HCAEC, Liver, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 36%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, CHD8, BCL6, CEBPA, MYCN, POU5F1, TBL1X, NFATC1, ZFX, POU4F2, XBP1, PPARG, ZBTB48, WT1, SMC1A, FOXA1, STAG2, TET2, KDM1A, YY1, RELA, ERG, ASCL1, ETS1, RUNX2, MYC, CDK6, SMARCA4, TOP1, SP140, RAD21, HIF1A, CHD7, RXRA, GRHL3, ATF2, GABPA, TAL1, MAX, ZNF143, CDK8, RCOR1, AGO2, CEBPB, NR2F2, TRIM28, CREB1, PIAS1, TFAP2C, EZH2, TP53, OCA2, KLF9, JUN, RBM22, ZHX2, SPI1, SP1, CTCF, BAF155, AR, HNF4A, BRD2, GSPT2, CBFA2T2, RXR, REST, ATF7, POU2F3, FLI1, JUND, BRD4, FOXP1, E2F1, SMC1, SMC3, ZNF92, STAG1, RBPJ
- Target gene symbol (double-evidenced CRMs): APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 80
- Number of somatic mutations (non-coding): 0
- Related genes and loops