- Basic information
- CohesinDB ID: CDBP00415345
- Locus: chr21-25926837-25927155
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Data sourse: GSE206145, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: Rad21,SA2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 50%,
"15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, XBP1, FOXA1, TFAP4, LYL1, ATF3, PRDM1, MECOM, PAX5, JMJD1C, TEAD1, TRIM28, KLF6, ETV1, LMO2, ESR1, OCA2, CTCF, JUN, TCF12, BAF155, SMC1, TEAD4, PDX1, POU2F2, TOP2A, RUNX1T1, ERF, STAT1, DDX5, ERG, PBX1, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, IKZF1, RCOR1, VDR, NR3C1, KMT2A, EZH2, FEZF1, SPI1, IRF1, GATA2, FLI1, RUNX1, SMC1A, CEBPA, LDB1, ZNF534, ZFX, ZNF384, RUNX2, GATA4, DAXX, HMGB2, PRDM9, FOS, CDK8, MYB, PIAS1, EVI1, RBM22, SP1, BCL11A, NR4A1, ASH2L, TCF3, FOXP1, BCOR, STAG2, STAG1, FOXA2, FOXF1, HOXB13, KDM1A, RELA, JUNB, GATA3, TAL1, MAX, GATA1, KLF4, NR2F2, TCF7L2, KDM5B, ZSCAN22, ELF3, AR, EGLN2, EGR1, NOTCH3, BRD4, JUND
- Target gene symbol (double-evidenced CRMs): APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 24
- Number of somatic mutations (non-coding): 3
- Related genes and loops