- Basic information
- CohesinDB ID: CDBP00415349
- Locus: chr21-25934006-25935829
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Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR000BLY, GSE131606, GSE108869, GSE165895, ENCSR000EFJ, ENCSR917QNE, GSE67783, GSE101921, GSE206145-NatGen2015, GSE116344, GSE94872, GSE206145, GSE85526, ENCSR620NWG, ENCSR635OSG, ENCSR853VWZ, ENCSR000HPG, ENCSR000EDE, GSE68388, ENCSR000ECS
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Cell type: RPE, Fibroblast, RH4, HEKn, Hep-G2, A-549, HUVEC, HCAEC, HeLa-S3, IMR-90, HSPC, SK-N-SH, Liver, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 55%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, E2F7, SOX2, XBP1, FOXA1, RXRB, TFAP4, ATF3, NFIC, RUNX3, CHD7, ZNF189, MECOM, MAF, JMJD1C, MYOG, TEAD1, TRIM28, ELF1, KLF6, ETV1, NFE2L2, SNAI2, LMO2, ESR1, HNF1B, TP73, OCA2, USF2, JUN, CTCF, TCF12, BAF155, EP300, SOX5, E2F4, E2F1, SMC1, TEAD4, ZNF92, FOXA3, ZNF175, GATAD2A, TFAP2C, EED, NANOG, POU5F1, RUNX1T1, ERF, ZNF317, STAT1, GATAD1, SAP130, HNF4G, HOXC5, ERG, NFKB2, ETS1, MYC, ONECUT1, HOMEZ, RAD21, FOXP2, RXRA, NKX2-1, BATF3, GABPA, STAT3, NKX3-1, RCOR1, NR2F6, VDR, ARNTL, NR3C1, ESRRA, CEBPB, ZNF750, KMT2A, CREB1, GRHL2, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, SSRP1, GATA2, ZNF644, SIX2, FLI1, MXI1, HCFC1R1, MRTFB, NFIL3, NCOA2, ETV5, RUNX1, SMC1A, BCL6, CEBPA, NKX2-2, EZH2phosphoT487, SIN3A, SOX13, SMAD3, CREBBP, RARA, RUNX2, CDK6, GATA4, ZNF184, ARNT, PBX4, DAXX, HMGB2, PRDM9, ATF2, SMAD4, ETV6, PBX3, FOS, CHD1, CDK8, MED1, ZEB1, TEAD3, CEBPD, MYB, PIAS1, SETDB1, EVI1, RBM22, MAFK, SP1, BCL11A, HNF4A, NR4A1, REST, ARID1A, ASH2L, TCF3, FOXP1, STAG2, ETV4, ZNF283, PPARG, FOXA2, CREM, CHD2, ZNF600, MAFF, ESR2, FOXF1, ZBTB33, HOXB13, KDM1A, YY1, RELA, NEUROD1, JUNB, AHR, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, AGO2, TLE3, KLF4, CEBPG, NR2F2, TCF7L2, NEUROG2, KDM5B, TP53, NFKB1, MYOD1, PHOX2B, ELF3, BRD2, ARRB1, TBX21, BHLHE40, AR, YAP1, ZNF366, EGR1, ZBTB26, RNF2, BRD4, JUND, MAZ, BRCA1, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 112
- Number of somatic mutations (non-coding): 8
- Related genes and loops