- Basic information
- CohesinDB ID: CDBP00415419
- Locus: chr21-26139601-26140849
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Data sourse: ShirahigeLab-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE131606, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE67783, GSE138405, GSE101921, ShirahigeLab-NatGen2015, ENCSR703TNG, ENCSR199XBQ, GSE116344, GSE94872, ENCSR193NSH, ShirahigeLab, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR767DFK, ENCSR217ELF, ENCSR853VWZ, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE126755, ENCSR000ECS
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Cell type: RH4, Liver, HuCC-T1, RPE, Fibroblast, HeLa-S3, IMR-90, HFFc6, SK-N-SH, RT-112, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HCAEC, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 51%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, LCORL, ZSCAN5C, ZNF660, NME2, FOXA1, RXRB, TFAP4, ATF3, NFIC, CHD7, ZBTB44, IKZF3, CBFB, ZNF189, SMARCE1, PAX5, MZF1, MITF, TEAD1, KLF6, ETV1, NFE2L2, KLF10, ZNF217, ESR1, HNF1B, OCA2, USF2, ZNF561, JUN, TCF12, CTCF, EP300, TAF3, MNT, SOX5, DPF2, SOX4, RFX5, E2F4, DEK, E2F1, ZNF528, SMC1, ZNF350, TEAD4, FOXA3, ZNF175, ZNF677, GATAD2A, GTF2F1, TFAP2C, RBPJ, CHD8, MYCN, CTBP1, ZBTB17, ZBTB48, STAT1, SRF, GATAD1, SAP130, TBP, ZNF300, PAX6, HOXC5, ERG, PRDM9, ZNF341, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, FOXP2, LHX2, RAD21, RXRA, NKX2-1, APC, STAT3, XRCC5, ZNF614, MIER3, RCOR1, NR2F6, NFE2, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, KLF8, BMPR1A, GRHL2, TRPS1, ZHX2, SPI1, ZNF664, IRF1, HDAC2, GATA2, ZNF644, FLI1, NR2C2, MXI1, ZGPAT, NFIL3, NFYB, ZNF554, NCOA2, MRTFB, ATF1, ETV5, RUNX1, THAP11, SMC1A, CBX1, CEBPA, SOX13, ZFX, SIN3A, AFF4, SMAD3, ZNF770, ERG3, ZNF513, SMARCC1, PRDM10, ZXDC, NFYC, RARA, CREBBP, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, DAXX, ARNT, NFIB, NRF1, HMGB2, ZNF48, HMBOX1, NFYA, SMAD4, FOXM1, PBX3, ZEB2, FOS, CDK8, CHD1, MED1, ZEB1, TEAD3, CEBPD, MYB, SCRT2, SMAD1, SUPT16H, NR1H2, KLF9, SETDB1, RBM22, MAFK, NIPBL, SP1, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZNF479, ZHX1, PHIP, MBD2, FOXP1, PRDM6, SMC3, ELL2, NCOR2, STAG2, STAG1, ZNF394, PPARG, FOXA2, CBX3, CREM, CHD2, PAF1, WT1, ZNF662, ZBTB33, CDK9, ZNF580, KDM1A, YY1, RELA, JUNB, ZNF267, ZNF830, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, HAND2, KLF4, CEBPG, SP7, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, NFKB1, MYOD1, BRD2, ELF3, KAT8, BHLHE40, AR, RXR, ZNF324, EGLN2, ZBTB26, BRD4, JUND, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 131
- Number of somatic mutations (non-coding): 5
- Related genes and loops