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Basic information

CohesinDB ID: CDBP00415745

Locus: chr21-27519144-27520086

Data sourse: ENCSR000EFJ, GSE138405, ENCSR000HPG, GSE206145, GSE206145-NatGen2015, GSE165895

Cell type: RPE, Hela-Kyoto, Fibroblast, IMR-90, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 36% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 79%, "7_Enh": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, FOXO1, PGR, FOXA2, EZH2phosphoT487, E2F7, SOX2, SMAD3, DUX4, FOXA1, FOXF1, HOXB13, TWIST1, ERG, RELA, JUNB, RUNX2, NFIC, GATA4, CHD7, LHX2, PBX4, RAD21, GATA3, GABPA, HMBOX1, TAL1, STAT3, PBX3, NKX3-1, FOS, MAX, RCOR1, FOXM1, MED1, NR3C1, ZNF750, CEBPB, ETV1, PIAS1, NEUROG2, NFE2L2, GRHL2, EBF3, CTCF, TCF12, JUN, EP300, BAF155, MAFK, BHLHE40, AR, GATA6, GATA2, ASH2L, BRD4, JUND, FOXP1, TEAD4, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): APP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 10

Related genes and loops

Related gene: ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415745