- Basic information
- CohesinDB ID: CDBP00416035
- Locus: chr21-28781296-28782228
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE25021, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, GSE165895, GSE93080, ENCSR000BKV, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE116344, GSE94872, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS
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Cell type: RH4, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, GM18486, HFFc6, GM18526, H1-hESC, GM18505, GM12878, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 19% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.633
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 79%,
"5_TxWk": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, SMC1A, ZNF316, FOXA2, MYCN, MAFG, XBP1, GTF2B, MAFF, FOXA1, SRF, ERG3, ERG2, TRIM22, HOXB13, HOXC5, YY1, ZBTB2, ZXDC, MYC, RUNX2, GATA4, RAD21, RXRA, NKX2-1, GATA3, HMBOX1, TAL1, STAT3, MAX, NRIP1, GATA1, ZNF143, TP63, NFE2, FOS, MED1, ZNF750, ESRRA, CEBPG, ZNF281, NR2F2, TRIM28, ZNF121, TEAD1, PIAS1, CEBPB, EZH2, ESR1, C11orf30, EBF3, CTCF, JUN, MAFK, BCL11A, PAX3-FOXO1, AR, HDAC2, GATA2, HSF1, BRD4, FOXP1, PRDM6, SMC1, SMC3, ZNF554, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): LTN1
- Function elements
- Human SNPs: QRS_complex_(12-leadsum)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 5
- Related genes and loops