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Basic information

CohesinDB ID: CDBP00416076

Locus: chr21-28938796-28941472

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE139435, GSE93080, GSE101921, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, Liver, Transformed-RPE1, TC-32, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, Ramos, GM19238, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 65% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.267

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 59%, "4_Tx": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, ZNF660, SOX2, FOXA1, HLF, RXRB, ATF3, ZBTB44, GLYR1, MXD4, MZF1, JMJD1C, TEAD1, TRIM28, ESR1, CTCF, TCF12, JUN, EP300, BAF155, TRIM24, IRF4, SMC1, TEAD4, KMT2B, FOXA3, GATAD2A, POU5F1, ZNF317, ZBTB17, DUX4, MLLT3, SRF, ERG, MYC, ZNF2, RAD21, STAT3, NKX3-1, RCOR1, NFE2, CEBPB, KMT2A, EBF3, SPI1, MIXL1, GATA2, MXD3, FLI1, ZGPAT, MRTFB, NFIL3, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, SIN3A, ZNF654, TWIST1, PRDM10, SMARCC1, ZBTB2, RUNX2, ZNF184, SOX11, ZNF48, SUPT5H, CDK8, HMGXB4, MED1, TEAD3, CEBPD, MYB, ZNF680, PIAS1, SMAD1, BCL11A, NR4A1, NKX2-5, REST, ASH2L, FOXP1, SMC3, STAG2, MLLT1, STAG1, SKI, PPARG, FOXA2, CHD2, MEIS1, ZNF692, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, ISL1, OTX2, GATA3, ZNF143, HAND2, KDM5B, TP53, ZNF213, PHOX2B, ELF3, KAT8, ARID4B, AR, HSF1, BRD4, TBX2

Target gene symbol (double-evidenced CRMs): LTN1,LINC00113,N6AMT1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 51

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000225298, ENSG00000156239, ENSG00000198862,

eachgene

Deatailed information for cohesin site CDBP00416076