- Basic information
- CohesinDB ID: CDBP00416161
- Locus: chr21-29229492-29236751
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE138405, GSE86191, GSE93080, GSE76893, GSE152721, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE116344, ENCSR000EEG, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE55407, GSE129526, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE73207
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Cell type: MDM, RH4, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, TF-1, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, A-549, GM19238, HeLa, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 41% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.400
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 35%,
"7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, MAFG, SMC1A, POU5F1, CHD2, TEAD4, ZNF317, ZBTB17, MAFF, FOXA1, CBX8, TRIM22, TBP, YY1, HDGF, ZNF384, NEUROD1, JUNB, RUNX2, CDK6, ZFP64, NFIC, RAD21, BRCA1, RUNX3, HIF1A, NKX2-1, ATF2, BATF, STAT3, MAX, PAX5, ETV6, FOS, CDK8, RCOR1, IKZF1, ARNTL, NR3C1, CEBPB, KLF4, TEAD1, TRIM28, KMT2A, BCLAF1, TCF7L2, NFE2L2, C11orf30, USF2, MYOD1, JUN, MAFK, SPI1, EP300, TBX21, ZBTB20, AR, PAX3-FOXO1, BHLHE40, DPF2, BCL11A, YAP1, IRF4, RFX5, ZHX1, DEK, ATF7, RNF2, IKZF2, JUND, BRD4, ZNF490, RELB, SMC3, GTF2F1, MLLT1, ZNF316, EED
- Target gene symbol (double-evidenced CRMs): BACH1
- Function elements
- Human SNPs: Alanine_aminotransferase_levels
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000156273,
- Related loop:
chr21:17700000-17725000~~chr21:29200000-29225000,
chr21:25450000-25475000~~chr21:29225000-29250000,
chr21:29075000-29100000~~chr21:29200000-29225000,
chr21:29225000-29250000~~chr21:29325000-29350000,
chr21:29225000-29250000~~chr21:29350000-29375000,
chr21:29230443-29234332~~chr21:29297765-29300738,
chr21:29232431-29234308~~chr21:29347637-29349372,
chr21:29232432-29234372~~chr21:29371556-29373423,
chr21:29232434-29234183~~chr21:29371542-29373242,
chr21:29232441-29234476~~chr21:29371286-29373596,
chr21:29232451-29234354~~chr21:29371361-29373472,
chr21:29232529-29234351~~chr21:29371520-29373447,
chr21:29232806-29234518~~chr21:29297832-29300927,
chr21:29235070-29236701~~chr21:29297903-29299607,