- Basic information
- CohesinDB ID: CDBP00416326
- Locus: chr21-29938518-29940831
-
Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE131956, GSE98367, GSE116868, ENCSR404BPV, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, GSE120943, ENCSR198ZYJ, ENCSR153HNT
-
Cell type: RPE, H1-hESC, Fibroblast, HCT-116, Monocytes, MB157, Neurons-H1, GBM39, K-562, HSPC, Macrophage, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
28% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"13_ReprPC": 33%,
"10_TssBiv": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: TRIM25, ZNF496, NME2, FOXA1, SUZ12, RING1B, UBTF, ATF3, CBFB, ZSCAN4, MITF, TRIM28, SNAI2, SAP30, ESR1, MED26, CTCF, EP300, BAF155, GATA6, RYBP, TRIM24, ZNF410, E2F1, ZNF175, JARID2, NANOG, CHD8, BRD1, ZSCAN5D, POU5F1, MYCN, ZNF263, KDM4C, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, TOP2A, ZNF563, DDX5, TBP, ERG, OGG1, MYC, SMARCA4, KDM4A, RAD21, TOP1, GRHL3, FOXP2, STAT3, XRCC5, IKZF1, NFE2, ZNF667, RCOR1, SRSF3, EZH2, PHF8, SPI1, HDAC2, GATA2, FLI1, MXI1, ATF1, RUNX1, EZH2phosphoT487, SIN3A, ZFX, POU4F2, TET2, RARA, SP3, NRF1, ZBTB10, CBFA2T3, CHD1, ZEB1, KDM6B, SCRT2, VEZF1, KLF9, SETDB1, GSPT2, ASH2L, PCGF2, BCOR, AATF, SMC3, STAG1, TRP47, ZNF283, FOXA2, TBL1X, RBBP5, MTA3, AGO1, WT1, CDK9, KDM1A, YY1, RELA, SP140, HIF1A, PCGF1, OTX2, GATA3, MAF1, MAX, TAL1, GATA1, MTA1, CBX2, PLAG1, NR2F1, KDM5B, ZNF334, BRD2, ARRB1, PAX3-FOXO1, AR, TAF1, RXR, HEXIM1, TFIIIC, HSF1, RNF2, NOTCH3, BRD4, ZBTB26, MAZ
- Target gene symbol (double-evidenced CRMs): GRIK1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 260
- Number of somatic mutations (non-coding): 17
- Related genes and loops
- Related gene:
ENSG00000171189,
- Related loop:
chr21:29575000-29600000~~chr21:29925000-29950000,
chr21:29925000-29950000~~chr21:30025000-30050000,
chr21:29925000-29950000~~chr21:30175000-30200000,
chr21:29925000-29950000~~chr21:30200000-30225000,
chr21:29925000-29950000~~chr21:30250000-30275000,
chr21:29925000-29950000~~chr21:30400000-30425000,
chr21:29943210-29945043~~chr21:30193229-30195738,
chr21:29943210-29945043~~chr21:30257090-30259197,
chr21:29943256-29945015~~chr21:30194046-30195747,
chr21:29943274-29945035~~chr21:30193637-30195774,
chr21:29943381-29944811~~chr21:30194078-30195728,
chr21:29943482-29944650~~chr21:30194059-30195711,