- Basic information
- CohesinDB ID: CDBP00416359
- Locus: chr21-30257534-30258308
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Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE143937, ENCSR000BKV, GSE138405, GSE76893, GSE101921, ENCSR703TNG, GSE106870, GSE116344, GSE145327, ENCSR895JMI, ENCSR768DOX, ENCSR879KXD, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000EHX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR748MVX, GSE131577
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Cell type: RH4, GM2610, CVB-hiPSC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, HMEC, HEKn, HeLa-S3, K-562, DKO, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, THP-1, HUES64, MCF-7, Hela-Kyoto, HCT-116, HL-60, MCF-10A, A-549, GM19238, OCI-AML-3
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 20% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.667
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
22% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 93%,
"9_Het": 5%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: SMC1A, FOXA2, NKX2-2, POU4F2, SMAD3, FOXA1, SRF, HOXB13, ERG, SMARCA4, RAD21, ARNT, HIF1A, GRHL3, NKX3-1, ZNF143, CREB1, PIAS1, SMAD1, STAG1, NFE2L2, TP53, ESR1, SETDB1, CTCF, MIXL1, PAX3-FOXO1, AR, REST, GATA2, JUND, BRD4, SMC1, SMC3, STAG2
- Target gene symbol (double-evidenced CRMs): TIAM1,GRIK1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 10
- Related genes and loops
- Related gene:
ENSG00000171189,
ENSG00000156299,
- Related loop:
chr21:29925000-29950000~~chr21:30250000-30275000,
chr21:29943210-29945043~~chr21:30257090-30259197,
chr21:30025000-30050000~~chr21:30250000-30275000,
chr21:30043713-30045634~~chr21:30257148-30259258,
chr21:30043756-30045614~~chr21:30257090-30259197,
chr21:30043774-30045603~~chr21:30257103-30259279,
chr21:30043897-30045697~~chr21:30256685-30258690,
chr21:30070984-30073381~~chr21:30257090-30259197,
chr21:30071470-30073906~~chr21:30257148-30259258,
chr21:30071597-30073842~~chr21:30257103-30259279,
chr21:30071764-30073904~~chr21:30256697-30259212,
chr21:30075000-30100000~~chr21:30250000-30275000,
chr21:30150000-30175000~~chr21:30250000-30275000,
chr21:30208954-30210477~~chr21:30257090-30259197,
chr21:30208982-30210528~~chr21:30257106-30259191,
chr21:30208984-30210508~~chr21:30257092-30259179,
chr21:30209042-30210435~~chr21:30257097-30258737,
chr21:30250000-30275000~~chr21:30400000-30425000,
chr21:30250000-30275000~~chr21:30500000-30525000,
chr21:30250000-30275000~~chr21:31050000-31075000,
chr21:30257134-30259115~~chr21:31179827-31181941,