- Basic information
- CohesinDB ID: CDBP00416475
- Locus: chr21-31142431-31143315
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE115602, GSE139435, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, GSE86191, GSE138405, GSE76893, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE106870, GSE94872, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, GSE110061, GSE111913, GSE155324, GSE38411, GSE68388, GSE83726, GSE126990, GSE50893, GSE131577
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Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, HuCC-T1, B-cell, H9-hESC, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, BCBL-1, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, HAP1, Macrophage, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HL-60, Hep-G2, HUVEC, GM19238, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 21% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.489
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
54% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 48%,
"15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: XBP1, ZFHX2, ATF3, ZNF362, CHD7, PAX5, MITF, TRIM28, ESR1, OCA2, CTCF, GATA6, SMC1, TEAD4, TFAP2C, RBPJ, GLIS1, POU2F2, CHD8, MYCN, POU5F1, TOP2A, ZBTB48, ZSCAN5A, SRF, DDX5, ERG2, ERG, MYC, RAD21, GRHL3, NKX2-1, STAT3, XRCC5, PRDM14, NR3C1, SRSF3, KMT2A, SIX2, FLI1, RUNX1, SMC1A, ZFX, SMAD3, ERG3, ZBTB2, ZNF384, RUNX2, ARNT, CDK8, ZEB1, SCRT2, KLF9, NCOA1, SETDB1, USF1, GSPT2, AATF, SMC3, STAG1, TBL1X, WT1, CDK9, HOXB13, YY1, RELA, SP140, HIF1A, GATA3, ZNF449, ZNF143, PLAG1, ZFP69B, NCOA3, TP53, BCL6B, EGR2, TBX21, AR, EGR1, HSF1, NOTCH3, BRD4, SCRT1, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): MIS18A,TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000156299,
ENSG00000159055,
- Related loop:
chr21:31097524-31100200~~chr21:31142192-31143682,
chr21:31097659-31100122~~chr21:31142126-31143686,
chr21:31097834-31100105~~chr21:31142031-31143645,
chr21:31097840-31099933~~chr21:31142156-31143409,
chr21:31097896-31099782~~chr21:31142212-31143628,
chr21:31108228-31109954~~chr21:31141372-31143715,
chr21:31108247-31110001~~chr21:31142031-31143645,
chr21:31108264-31109975~~chr21:31142192-31143682,
chr21:31125000-31150000~~chr21:31250000-31275000,
chr21:31125000-31150000~~chr21:31575000-31600000,
chr21:31125000-31150000~~chr21:32275000-32300000,