- Basic information
- CohesinDB ID: CDBP00416482
- Locus: chr21-31160575-31161697
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Data sourse: GSE67783, GSE86191, GSE98367, ENCSR000BLY, ENCSR000EHW, GSE206145-NatGen2015, GSE120943, ENCSR000EHX
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Cell type: Fibroblast, HCT-116, Monocytes, SK-N-SH, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
54% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 31%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, FOXA1, HLF, TFAP4, CHD7, PRDM1, MORC2, MITF, ZNF467, MAF, JMJD1C, KLF5, ELF1, TRIM28, TEAD1, LMO2, SAP30, OCA2, MED26, PITX3, USF2, CTCF, TCF12, EP300, ARID5B, LMO1, TRIM24, ZNF410, E2F1, TEAD4, KMT2B, PDX1, TFAP2C, RBPJ, NANOG, CHD8, BRD1, POU5F1, MYCN, CDK7, MTA2, DUX4, ZSCAN5A, ZNF205, SRF, ERG, PBX1, ETS1, MYC, SMARCA4, EOMES, RAD21, LHX2, GRHL3, GABPA, IKZF1, NFE2, TERF2, RCOR1, VDR, NR3C1, CEBPB, KMT2A, EZH2, GRHL2, EBF3, SPI1, GATA2, FLI1, MXI1, RELB, NFIL3, MRTFB, RUNX1, CTNNB1, SMC1A, BCL6, CEBPA, NKX2-2, SIN3A, ZFX, POU4F2, SMAD3, ERG3, TWIST1, ZNF35, NOTCH1, RUNX2, SMAD2, ARNT, PRDM9, SMAD4, PBX3, FOXM1, CDK8, MED1, MYB, USF1, NIPBL, SP1, BCL11A, NR4A1, REST, ASH2L, HNRNPLL, BCOR, FOXP1, SMC3, ELL2, STAG1, FOXA2, RBBP5, CHD2, PAF1, WT1, MEF2C, ZBTB33, CDK9, KDM1A, RELA, HIF1A, PCGF1, GATA3, TAL1, MAX, NRIP1, HAND2, BCL11B, NR2F2, TCF7L2, TP53, MED, MYOD1, BRD2, T, TBX21, PAX3-FOXO1, AR, ZBTB16, RXR, NOTCH3, BRD4, IKZF2, CLOCK, MAZ, TBX2, FOSL2
- Target gene symbol (double-evidenced CRMs): BACH1,MIS18A,TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 20
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000156273,
ENSG00000156299,
ENSG00000159055,
- Related loop:
chr21:29275000-29300000~~chr21:31150000-31175000,
chr21:30675000-30700000~~chr21:31150000-31175000,
chr21:31000000-31025000~~chr21:31150000-31175000,
chr21:31150000-31175000~~chr21:31250000-31275000,
chr21:31150000-31175000~~chr21:31375000-31400000,
chr21:31150000-31175000~~chr21:31575000-31600000,
chr21:31150000-31175000~~chr21:32250000-32275000,