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Basic information

CohesinDB ID: CDBP00416501

Locus: chr21-31218747-31219814

Data sourse: GSE38395, ENCSR000BTU, GSE93080, ENCSR000EAC, GSE72082, GSE86191, GSE131956, ENCSR000BSB, GSE138405, GSE129526, GSE111913, GSE206145-NatGen2015, GSE68388, GSE25021

Cell type: MCF-7, Hela-Kyoto, Fibroblast, HCT-116, Ishikawa, GM12878, hLCL, GBM39, RT-112, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 54% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 30%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, HMG20A, SOX2, PATZ1, FOXA1, PBX2, MLL4, ZFHX2, HDGF, ATF3, NFIC, ZC3H8, ZNF362, ZBTB44, CHD7, IKZF3, ZNF189, PAX5, TP63, MZF1, ZNF467, ZNF629, KLF5, TEAD1, ELF1, ZNF573, KLF6, TRIM28, NFE2L2, SAP30, ESR1, OCA2, RCOR2, ZNF561, CTCF, TCF12, JUN, BAF155, KLF1, EP300, MNT, GATA6, SOX5, DPF2, E2F4, ZNF674, RAD51, E2F1, ZNF528, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, EED, RBPJ, GLIS1, POU2F2, BRD1, ZNF263, MYCN, POU5F1, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, STAT1, NBN, ERG2, SP4, HNF4G, ERG, HOXC5, ZNF341, MYC, SMARCA4, TSHZ1, RAD21, LHX2, GRHL3, STAT3, XRCC5, SOX10, NKX3-1, PRDM14, IKZF1, RCOR1, HNRNPH1, ZNF750, CEBPB, ESRRA, NR3C1, KMT2A, CREB1, EZH2, GRHL2, FEZF1, EBF3, SPI1, EHF, KLF17, HDAC2, GATA2, GATAD2B, SIX2, FLI1, SMARCA5, RELB, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, SIN3A, ZFX, ZNF335, SOX13, SMAD3, ERG3, TRIM22, SMARCC1, ZNF18, CREBBP, ZNF384, ZNF35, RUNX2, GATA4, OSR2, ZNF184, PBX4, DAXX, ARNT, ATF2, ZEB2, FOXM1, MAFB, SP2, FOS, CDK8, MED1, SCRT2, SMAD1, KLF9, ZNF22, SP1, BCL11A, NIPBL, HNF4A, REST, ZBTB7A, ATF7, POU2F3, ASH2L, HOXA9, PHIP, FOXP1, PRDM6, SMC3, ELL2, NCOR2, MLLT1, NFATC3, MEF2B, PPARG, FOXA2, EBF1, MEIS1, SS18, PAF1, ZNF600, ZSCAN16, WT1, ZNF30, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, BRG1, ZIC2, HIF1A, SKIL, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, SPIB, KLF4, CEBPG, SP7, NR2F2, TCF7L2, TP53, PKNOX1, ZBTB6, ZNF687, NFKB1, MYOD1, EGR2, PHOX2B, T, BRD2, TBX21, BHLHE40, AR, TAF1, ZBTB40, RXR, ZBTB42, EGR1, IKZF2, BRD4, SCRT1, NOTCH3, MAZ, FOSL2

Target gene symbol (double-evidenced CRMs): MIS18A,HUNK,TIAM1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 20

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156299, ENSG00000142149, ENSG00000159055,

eachgene

Deatailed information for cohesin site CDBP00416501