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Basic information

CohesinDB ID: CDBP00416515

Locus: chr21-31264477-31265037

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE25021, ENCSR000BTU, ENCSR000BKV, GSE86191, GSE138405, ENCSR703TNG, GSE106870, GSE145327, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, GSE110061, GSE129526, GSE50893

Cell type: MCF-7, GM12892, GM2630, H1-hESC, HCT-116, Hela-Kyoto, MDM, SNYDER, CVB-hiPSC, GM19240, Ishikawa, GM2588, HUES64, SK-N-SH, K-562, THP-1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 59% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 52%, "5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXA1, TP63, MITF, TEAD1, ZNF121, TRIM28, ETV1, ESR1, CTCF, BAF155, TRIM24, E2F1, PDX1, POU2F2, NANOG, MYCN, ZNF263, TOP2A, RUNX1T1, POU5F1, ZBTB48, ZSCAN5A, STAT1, DUX4, SRF, DDX5, ERG, PBX1, OGG1, ZNF341, MYC, RAD21, GRHL3, GABPA, APC, STAT3, NKX3-1, PRDM14, KMT2A, EZH2, SPI1, GATA2, FLI1, RUNX1, SMC1A, NKX2-2, ZFX, TET2, ERG3, RUNX2, GATA4, MED1, MYB, PIAS1, ZNF3, REST, ARID1A, FOXP1, SMC3, STAG1, TRP47, TBL1X, FOXA2, PAF1, ZNF600, WT1, HOXB13, KDM1A, YY1, RELA, NEUROD1, BRG1, SP140, HIF1A, OTX2, TAL1, ZNF143, TLE3, NCOA3, TP53, ZNF334, EGR2, BHLHE40, AR, RXR, HSF1, NOTCH3, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): GRIK1,SCAF4,TIAM1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000171189, ENSG00000156299, ENSG00000156304,

eachgene

Deatailed information for cohesin site CDBP00416515