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Basic information

CohesinDB ID: CDBP00416548

Locus: chr21-31342251-31342878

Data sourse: GSE103477, GSE98367, GSE73207

Cell type: MDM, TF-1, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SMC3,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 59% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 25%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NME2, FOXA1, MLL4, HDGF, IKZF3, ZNF383, PAX5, TEAD1, LMO2, OCA2, MED26, ZNF561, ZNF157, E2F4, ZNF528, JARID2, NANOG, BRD3, POU5F1, TOP2A, ZNF263, CTBP1, ERF, DUX4, STAT1, ERG, ZBTB21, NFKB2, SMARCA4, FOXK2, ZNF398, RCOR1, CEBPB, CREB1, GABPB1, KLF17, GATA2, FLI1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, REPIN1, TRIM22, SMARCC1, PRDM10, ZBTB10, ATF2, FOXM1, SP2, PIAS1, STAT5A, GSPT2, RBM25, ELL2, NFATC3, CBFA2T2, CBX3, SS18, ZSCAN16, WT1, MEF2C, JUNB, ZFP36, BATF, SPIB, KLF4, ZFP69B, MED, EGR2, ELF3, RXR, EGLN2, HSF1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ATF3, ZFP64, CBFB, TP63, MITF, ZNF467, MYOG, MAF, JMJD1C, ELF1, SNAI2, CTCF, JUN, ZBTB20, MNT, DPF2, RYBP, PDX1, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NBN, ONECUT1, ZNF2, KDM4A, RXRA, PRDM14, VDR, NR3C1, ESRRA, STAT5B, KMT2A, KLF8, GRHL2, EBF3, ZKSCAN5, ZBTB14, SMARCA5, ZBTB24, EZH2phosphoT487, AFF4, POU4F2, ZNF770, ZNF513, ZNF18, SP3, DAXX, ARNT, BACH1, PRDM9, ZEB2, PBX3, NCAPH2, MAFB, ZNF10, ZXDB, ZNF680, KLF9, ZNF41, SP1, TFAP2A, BCL11A, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, SMC3, STAG1, MLLT1, ZNF394, TRP47, EBF1, MEIS1, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, ZNF768, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, TBX21, TFIIIC, RNF2, IKZF2, BRD4, JUND, PGR, SOX2, PATZ1, BMI1, CHD7, ZNF189, SMARCE1, MZF1, KLF6, ZNF217, ESR1, SAP30, TP73, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, MYC, KLF12, NKX2-1, GABPA, STAT3, IKZF1, EZH2, PHF8, SPI1, HDAC2, INTS13, GATAD2B, NCOA2, ZNF554, ZNF76, SIN3A, ERG3, CREBBP, ZNF35, ZNF384, ZNF518A, CDK8, ZMYM3, REST, HNRNPLL, BCOR, FOXP1, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, RELA, TARDBP, SKIL, MAX, NR2F1, KDM5B, PKNOX1, MYOD1, T, AR, ZBTB16, YAP1, ZNF324, HEXIM1, AHR, FOSL2, MBD3, ZSCAN5C, SUZ12, ZFHX2, NFIC, PRDM1, ZNF629, KLF5, TRIM28, ETV1, TCF12, EP300, BAF155, RAD51, ZNF512B, E2F1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF639, ARNTL, ZNF750, FEZF1, TRPS1, EHF, IRF1, MRTFB, MYF5, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, RUNX2, SMAD2, CDK6, OSR2, ZNF184, GATA4, PBX4, NRF1, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, L3MBTL2, KLF16, NIPBL, ZBTB7A, PHIP, NELFA, ZNF283, FOXA2, RBBP5, ZNF600, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, ZNF449, GATA1, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): TIAM1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156299,

eachgene

Deatailed information for cohesin site CDBP00416548