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Basic information

CohesinDB ID: CDBP00416550

Locus: chr21-31346173-31348564

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, SLK, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, GM19238, HeLa, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 55% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.400

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 59% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 27%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SMC1A, FOXA2, ZNF263, ZNF660, NKX2-2, ZNF600, ZSCAN21, ZNF317, ZNF692, STAG2, ZBTB17, ZBTB48, SMAD3, SRF, ZNF654, SUZ12, MEF2C, FOXA1, TRIM22, HOXB13, SMARCC1, XBP1, HOXC5, ZBTB2, ZNF35, JUNB, GATA4, RFX1, CTCFL, RAD21, ZBTB44, IKZF3, HIF1A, ARNT, GRHL3, NKX2-1, ZEB2, ZSCAN4, NKX3-1, ZNF143, DACH1, MED1, ZNF629, CEBPB, TEAD1, SCRT2, PIAS1, CREB1, EZH2, KDM5B, TP53, ESR1, KLF9, OCA2, GRHL2, TBX5, ZNF561, PHOX2B, CTCF, BRD2, NIPBL, AR, IRF1, TAF1, GATA6, NKX2-5, REST, ZNF479, GATA2, ASH2L, IKZF2, BRD4, PHIP, ILF3, FOXP1, ZNF528, SMC1, ZSCAN23, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): TIAM1

Function elements

Human SNPs: Epithelial_ovarian_cancer

Number of somatic mutations (coding): 26

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000156299,

eachgene

Deatailed information for cohesin site CDBP00416550