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Basic information

CohesinDB ID: CDBP00416563

Locus: chr21-31385756-31388309

Data sourse: GSE67783, GSE86191, GSE98367, GSE132649, GSE116868, GSE206145, GSE62063, GSE120943, GSE131606

Cell type: RPE, T-47D, HCT-116, Monocytes, MB157, HSPC, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 59% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 74%, "14_ReprPCWk": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, CHD8, BRD1, TBL1X, POU5F1, MYCN, ZNF263, SOX2, ZFX, POU4F2, XBP1, ZSCAN5D, ZBTB48, WT1, STAT1, ZSCAN5A, KDM4C, NME2, ERG3, SUZ12, ZNF770, ERG2, LEO1, HOXB13, ZFHX2, PRDM10, ERG, YY1, RELA, CREBBP, ZNF384, OGG1, ATF3, MYC, SP140, GRHL3, ARNT, HIF1A, SMC3, APC, STAT3, MAFB, ZSCAN4, ZNF143, GATA1, RCOR1, ZNF736, PLAG1, ZFP69B, ESRRA, ZEB1, TRIM28, SCRT2, NR2F1, SNAI2, EZH2, KDM5B, ZMYM3, OCA2, GRHL2, ZNF334, EGR2, PHOX2B, CTCF, PAX3-FOXO1, AR, CBFA2T2, FOXA2, RXR, RBM25, HEXIM1, HSF1, HNRNPLL, SCRT1, BRD4, MAZ, AATF, TEAD4, STAG1

Target gene symbol (double-evidenced CRMs): TIAM1,HUNK,SCAF4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 36

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156299, ENSG00000156304, ENSG00000142149,

eachgene

Deatailed information for cohesin site CDBP00416563