- Basic information
- CohesinDB ID: CDBP00416586
- Locus: chr21-31443697-31445240
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Data sourse: GSE206145-NatGen2015, GSE67783, GSE122299, GSE98367
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Cell type: Macrophage, Fibroblast, HSPC, HEK293T
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Mau2,SMC3,SA1,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
59% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 53%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NCOA2, GLIS1, RUNX1, POU2F2, SMC1A, MEF2B, CEBPA, EZH2phosphoT487, EBF1, TOP2A, PAF1, ZFX, CTBP1, TEAD4, POU5F1, SMAD3, ZNF30, STAT1, FOXA1, FOXF1, ZNF770, MEF2C, HOXB13, ZNF18, ERG, RELA, ZNF35, ZNF384, ZNF341, GATA4, OSR2, ZNF184, ZFP64, ZBTB44, RAD21, ARNT, GATA3, BATF, ZNF189, SMARCE1, MAX, STAT3, NRIP1, MZF1, CDK8, MAFB, KLF4, ZNF750, CEBPB, KLF5, TEAD1, NR2F2, ZNF506, TRIM28, BCL11B, ETV1, EZH2, KMT2A, ESR1, STAT5B, ZNF573, GRHL2, ZNF334, ZNF561, CTCF, BAF155, SPI1, ZBTB20, AR, GATA6, PAX8, HDAC2, YAP1, ZNF182, ZBTB42, POU2F3, HSF1, CTBP2, PHIP, BRD4, PRDM6, ZIM3, AHR
- Target gene symbol (double-evidenced CRMs): TIAM1
- Function elements
- Human SNPs: Renal_sinus_fat
- Number of somatic mutations (coding): 34
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000156299,
- Related loop:
chr21:27500000-27525000~~chr21:31450000-31475000,
chr21:31075000-31100000~~chr21:31450000-31475000,
chr21:31175000-31200000~~chr21:31450000-31475000,
chr21:31200000-31225000~~chr21:31425000-31450000,
chr21:31200000-31225000~~chr21:31450000-31475000,
chr21:31325000-31350000~~chr21:31425000-31450000,
chr21:31450000-31475000~~chr21:31550000-31575000,
chr21:31450000-31475000~~chr21:31575000-31600000,
chr21:31450000-31475000~~chr21:31600000-31625000,