- Basic information
- CohesinDB ID: CDBP00416595
- Locus: chr21-31457163-31460889
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE25021, GSE143937, GSE93080, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE76893, GSE101921, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE98367, ENCSR193NSH, GSE206145, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR748MVX
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Cell type: MDM, RH4, CVB-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, HEKn, Ishikawa, HeLa-S3, K-562, DKO, H1-hESC, SNYDER, GM12878, GM2588, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, HeLa, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 34% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.611
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
59% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 71%,
"5_TxWk": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GLIS1, ZNF283, POU2F2, SMC1A, CHD8, ZSCAN5D, POU5F1, ZNF660, ZFX, STAG2, XBP1, ZBTB17, ZBTB48, SMAD3, ZSCAN5A, ZNF574, ZNF654, SRF, ERG3, PBX2, ERG2, ZNF770, ZNF18, PRDM10, MEF2A, RELA, ZBTB2, ZNF35, HDGF, NOTCH1, CTCFL, RAD21, ARNT, HIF1A, TAL1, XRCC5, MZF1, MAX, PAX5, CDK8, STAT5B, KDM5B, ESR1, TP53, ZBTB6, OCA2, GTF3C2, ZNF334, NFKB1, ZNF561, KLF16, CTCF, PHOX2B, EP300, SPI1, AR, REST, ZNF324, EGLN2, ZBTB42, HSF1, ZNF528, SMC1, RELB, SMC3, MEF2D, STAG1
- Target gene symbol (double-evidenced CRMs): TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 30
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000156299,
- Related loop:
chr21:27500000-27525000~~chr21:31450000-31475000,
chr21:31075000-31100000~~chr21:31450000-31475000,
chr21:31175000-31200000~~chr21:31450000-31475000,
chr21:31197648-31199955~~chr21:31457221-31458650,
chr21:31200000-31225000~~chr21:31450000-31475000,
chr21:31346727-31348487~~chr21:31457134-31458652,
chr21:31450000-31475000~~chr21:31550000-31575000,
chr21:31450000-31475000~~chr21:31575000-31600000,
chr21:31450000-31475000~~chr21:31600000-31625000,
chr21:31458665-31460618~~chr21:31579948-31582262,