Deatailed information for cohesin site CDBP00416619

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  • Basic information
  • CohesinDB ID: CDBP00416619
  • Locus: chr21-31508568-31510430
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE122299, GSE138405, GSE86191, GSE76893, GSE152721, GSE130135, ENCSR703TNG, GSE106870, GSE94872, GSE98367, ENCSR193NSH, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR748MVX
  • Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, HAP1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, GM19238, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 31% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.478
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 67% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "15_Quies": 38%, "7_Enh": 27%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF660, ZSCAN5C, SOX2, PATZ1, FOXA1, SUZ12, MLL4, ZFHX2, HDGF, ATF3, INSM2, ZFP64, CTCFL, ZBTB44, RUNX3, IKZF3, ZNF444, ZNF322, KLF14, ZNF189, SMARCE1, PAX5, MZF1, MITF, ZNF320, BACH2, ZNF467, ZNF629, MAF, KLF5, ELF1, TRIM28, TEAD1, KLF6, BCLAF1, NFE2L2, KLF10, ZNF217, ESR1, ZNF561, CTCF, TCF12, JUN, KLF1, ZNF695, LMO1, MNT, DPF2, SOX4, E2F6, IRF4, TRIM24, RAD51, ZNF423, E2F1, ZNF528, SMC1, ZNF350, TEAD4, PDX1, TFAP2C, EED, GLIS1, POU2F2, CHD8, BRD1, ZSCAN5D, POU5F1, MYCN, ZNF263, BRD3, CDK7, RUNX1T1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, STAT1, CTBP1, ZNF317, SRF, ZSCAN21, DUX4, NBN, ERG2, SP4, HOXC5, ERG, ZBTB8A, MYC, SMARCA4, ZNF2, ARID1B, RAD21, FOXP2, GRHL3, KDM4A, NKX2-1, FOXK2, BATF3, GABPA, APC, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, MIER3, ZNF639, NFE2, ARNTL, NR3C1, ESRRA, ZNF750, CEBPB, STAT5B, KMT2A, CREB1, FOXK1, EZH2, KLF8, GRHL2, FEZF1, SPI1, HES1, MIXL1, KLF17, IRF1, HDAC2, GATA2, GATAD2B, FLI1, HCFC1, SMARCA5, RELB, MRTFB, NCOA2, ZNF554, PTBP1, RUNX1, CBX1, MAFG, SMC1A, NKX2-2, SIRT6, CEBPA, ZNF335, ZFX, SIN3A, AFF4, HDAC1, SMAD3, REPIN1, ZNF770, ERG3, TRIM22, ZNF18, PRDM10, SMARCC1, MEF2A, CREBBP, ZXDC, ZNF35, ZBTB2, RUNX2, GATA4, OSR2, ZNF184, SP3, ARNT, PBX4, BACH1, CBX3, ZNF48, ATF2, ZEB2, ZNF518A, PBX3, FOXM1, CBFA2T3, FOS, CDK8, MED1, ZEB1, TEAD3, ZXDB, MYB, ZNF680, DIDO1, ZNF331, PML, ZNF3, ZMYM3, KLF9, C11orf30, L3MBTL2, SETDB1, STAT5A, KLF16, USF1, BCL11A, NIPBL, SP1, TFAP2A, MAFK, REST, ZBTB7A, RBM25, ZSCAN31, ATF7, ASH2L, HOXA9, PHIP, GLIS2, BCOR, SMC3, ELL2, ZNF34, STAG1, MLLT1, CXXC4, NFATC3, ZNF394, MEF2B, ZNF316, FOXA2, ZNF207, EBF1, RBBP5, PAF1, E2F8, ZNF600, ZNF692, GTF2B, WT1, MTA3, CREM, MAFF, ZNF30, ZNF574, ZSCAN16, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, SP140, ZIC2, SKIL, HIF1A, ZFP36, GATA3, BATF, MGA, TAL1, MAX, ZNF143, MTA1, GATA1, PLAG1, BCL6, KLF4, ZFP69B, SP7, NCOA3, NR2F2, TCF7L2, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, ZSCAN22, NFKB1, EGR2, ELF3, BRD2, NANOG, TBX21, BHLHE40, AR, PAX3-FOXO1, ZNF324, EGLN2, ZBTB42, EGR1, RB1, HSF1, ZBTB26, IKZF2, JUND, NOTCH3, BRD4, CLOCK, RNF2, MAZ, ILF3, ZSCAN23, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): TIAM1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 20
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000156299,
  • Related loop: chr21:27500000-27525000~~chr21:31500000-31525000, chr21:31175000-31200000~~chr21:31500000-31525000, chr21:31197748-31199515~~chr21:31508678-31510577, chr21:31250000-31275000~~chr21:31500000-31525000, chr21:31325000-31350000~~chr21:31500000-31525000, chr21:31346852-31348335~~chr21:31508604-31510568, chr21:31346859-31348357~~chr21:31514086-31515684, chr21:31350000-31375000~~chr21:31500000-31525000, chr21:31375000-31400000~~chr21:31500000-31525000,
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