- Basic information
- CohesinDB ID: CDBP00416622
- Locus: chr21-31514452-31515240
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EAC, GSE67783, GSE86191, GSE76893, GSE101921, GSE206145-NatGen2015, GSE130135, ENCSR703TNG, GSE116344, GSE94872, GSE76815, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE131956, GSE110061, GSE129526, GSE111913, GSE83726, GSE50893
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Cell type: RH4, Liver, H9-hESC, HMEC, Fibroblast, H1-hESC, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, Macrophage, HUES64, MCF-7, GM12892, HCT-116, HEK293T, Hep-G2, Neurons-H1, HUVEC, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 18% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 45%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, FOXA1, ZFHX2, ZNF362, ZBTB44, CHD7, ZNF189, MITF, ZNF586, TRIM28, ZNF121, LMO2, ESR1, OCA2, PITX3, ZNF561, CTCF, TCF12, BAF155, EP300, LMO1, ZNF528, SMC1, TEAD4, PDX1, TFAP2C, EED, RBPJ, GLIS1, CHD8, BRD1, ZSCAN5D, ZNF263, POU5F1, MYCN, ZBTB17, ZBTB48, ZSCAN5A, DDX5, ERG2, ZNF300, ERG, ASCL1, ZBTB8A, ZNF2, RAD21, NKX2-1, GABPA, STAT3, XRCC5, RCOR1, HNRNPH1, CEBPB, KMT2A, EZH2, FEZF1, EBF3, SPI1, HDAC2, GATA2, MXD3, MXI1, RUNX1, SMC1A, BCL6, CEBPA, ZFX, SMAD3, ZBTB12, ZNF654, ERG3, TWIST1, PRDM10, ZNF549, ZBTB2, ZNF35, GATA4, OSR2, ZNF184, PBX4, ARNT, PRDM9, ZEB2, FOXM1, MYB, ZNF680, KLF9, STAT5A, USF1, NIPBL, REST, ZNF479, RBM25, ASH2L, PHIP, BCOR, FOXP1, SMC3, STAG1, FOXA2, TBL1X, RBBP5, CHD2, PAF1, ZNF600, ZNF692, WT1, KDM1A, YY1, ZIC2, HIF1A, GATA3, TAL1, HAND2, CEBPG, NCOA3, TCF7L2, KDM5B, TP53, ZBTB6, ZNF547, MYOD1, EGR2, ELF3, AR, TAF1, ZNF324, ZBTB42, HSF1, BRD4, MAZ, TBX2, AHR
- Target gene symbol (double-evidenced CRMs): TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000156299,
- Related loop:
chr21:27500000-27525000~~chr21:31500000-31525000,
chr21:31175000-31200000~~chr21:31500000-31525000,
chr21:31197748-31199515~~chr21:31508678-31510577,
chr21:31250000-31275000~~chr21:31500000-31525000,
chr21:31325000-31350000~~chr21:31500000-31525000,
chr21:31346852-31348335~~chr21:31508604-31510568,
chr21:31346859-31348357~~chr21:31514086-31515684,
chr21:31350000-31375000~~chr21:31500000-31525000,
chr21:31375000-31400000~~chr21:31500000-31525000,