- Basic information
- CohesinDB ID: CDBP00416643
- Locus: chr21-31554393-31555120
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Data sourse: ENCSR000BLD, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE104888, ENCSR000BSB, GSE129526, GSE105028, GSE206145, ENCSR000ECE, GSE68388, GSE97394, GSE50893
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Cell type: RPE, H1-hESC, HCT-116, GM10847, HEK293T, GM12878, GM2588, HUES64, H9-hESC, HuCC-T1, B-cell
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 33%,
"7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, MLL4, HDGF, ZBTB44, IKZF3, MORC2, ZNF383, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, ZNF561, ARID5B, E2F4, ZNF674, ZNF528, JARID2, NANOG, ZNF263, BRD3, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ERG, ZBTB21, ZBTB8A, NFKB2, SMARCA4, RFX1, ZNF398, RCOR1, CEBPB, CREB1, ZHX2, ZNF257, KLF17, SIX2, FLI1, HCFC1, MXI1, ZNF785, RELB, RUNX1, ZMYM2, HDAC1, NKX2-2, IRF3, REPIN1, TET2, TRIM22, SMARCC1, PRDM10, TFDP1, ZBTB10, ATF2, FOXM1, SP2, PIAS1, ARID2, RBM25, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, ZNF207, CHD2, PAF1, SS18, ZSCAN16, WT1, JUNB, NEUROD1, BATF, MAF1, ZFP69B, KLF4, BCL11B, ZBTB6, MED, EGR2, ELF3, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, FOSL1, ZNF660, XBP1, PBX2, ZNF596, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, ZNF273, ZSCAN4, TP63, BACH2, ZNF467, MAF, ELF1, SNAI2, KLF10, ZNF624, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, ZNF423, DDX20, ZNF350, PDX1, TFAP2C, RBPJ, ZNF239, MTA2, ZBTB17, ZSCAN21, ZBTB48, SRF, DDX5, NBN, PBX1, ONECUT1, ZNF2, TSHZ1, FOXP2, KDM4A, RXRA, NKX3-1, PRDM14, TERF2, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, KDM5A, ZBTB14, SSRP1, ZNF146, SMARCA5, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZNF18, CEBPZ, SP3, ARNT, BACH1, NFIB, PRDM9, ZEB2, PBX3, MAFB, ZNF10, NCAPH2, ZXDB, TAF7, KLF9, USF1, BCL11A, TFAP2A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, MLLT1, STAG1, ZNF394, TRP47, EBF1, ZNF580, ZKSCAN1, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, PRDM2, CUX1, ZSCAN23, TBX2, ZNF468, CBX5, PGR, SOX2, PATZ1, RING1B, LEO1, TFAP4, CHD7, ZNF189, SMARCE1, MZF1, KLF6, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, SOX4, E2F6, RFX5, PRKDC, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ZMYND8, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, STAT3, IKZF1, EZH2, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF76, ZNF554, NFYB, BCL6, SIN3A, ZFP37, ERG3, MEF2A, CREBBP, ZNF35, ZNF384, RARA, ZNF169, TAF15, ZNF518A, CDK8, ZEB1, ZMYM3, MAFK, REST, ZNF543, BCOR, FOXP1, AATF, CXXC4, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, RELA, TARDBP, SKIL, ZNF611, MAX, TCF7L2, NR2F1, KDM5B, ZNF791, PKNOX1, ZNF547, MYOD1, T, AR, ZNF324, HEXIM1, ZNF280D, FOSL2, MBD3, ZNF391, ZSCAN5C, SUZ12, ZFHX2, INSM2, ZNF362, CTCFL, PRDM1, KLF14, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, COBLL1, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, ZNF512B, E2F1, TEAD4, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ARID3A, ASCL1, ZNF341, EOMES, RAD21, GRHL3, APC, NFE2, ZNF639, ZNF750, FEZF1, EHF, IRF1, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, NMYC, TWIST1, NOTCH1, RUNX2, ZSCAN30, OSR2, ZNF184, PBX4, NRF1, CHD1, FOS, SUPT5H, MED1, KDM6B, MYB, SCRT2, ZNF558, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, ZNF783, NELFA, FOXA2, RBBP5, E2F8, ZNF600, FOXF1, CDK9, HOXB13, YY1, ASXL1, SP140, HIF1A, OTX2, ZNF449, GATA1, SP7, NCOA3, NR2F2, ZNF687, ZNF213, BHLHE40, TAF1, ZNF579, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 6
- Number of somatic mutations (non-coding): 3
- Related genes and loops