- Basic information
- CohesinDB ID: CDBP00416649
- Locus: chr21-31565297-31567564
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE126634, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, GSE116344, GSE94872, ENCSR000EEG, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000EHX, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, GSE126990, GSE50893
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Cell type: MDM, RH4, GM10847, GM2610, GM19240, HSPC, Liver, H9-hESC, RPE, GM2630, HMEC, Fibroblast, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, GM19238, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 28% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.511
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 51%,
"14_ReprPCWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NANOG, SMC1A, POU2F2, TBL1X, MYCN, ZSCAN5D, CBX1, SOX2, ZFX, TEAD4, STAG2, XBP1, WT1, MAFF, SMAD3, POU4F2, FOXA1, ZNF770, SRF, ERG3, STAT1, ARID3A, CDK9, HOXB13, SMARCC1, TBP, KDM1A, RELA, ZBTB2, ZNF35, ZNF384, CREBBP, ZBTB48, AHR, MYC, RUNX2, EZH1, RBBP5, CHD7, PRDM1, RAD21, ARNT, HIF1A, BACH1, ZFP36, ATF2, MAX, XRCC5, ZNF143, ZNF467, KLF4, ESRRA, GFI1B, TEAD3, ZNF121, TEAD1, CREB1, EZH2, ESR1, ZNF22, CTCF, MAFK, BCL11A, USF1, MNT, BHLHE40, IRF4, EGLN2, POU2F3, NCOR1, MXI1, BRD4, CLOCK, MAZ, SMC1, SMC3, STAG1, ZNF316
- Target gene symbol (double-evidenced CRMs): TIAM1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 20
- Related genes and loops
- Related gene:
ENSG00000156299,
- Related loop:
chr21:31175000-31200000~~chr21:31550000-31575000,
chr21:31197589-31199959~~chr21:31565573-31567413,
chr21:31197748-31199515~~chr21:31565524-31567074,
chr21:31197753-31199935~~chr21:31565273-31566860,
chr21:31200000-31225000~~chr21:31550000-31575000,
chr21:31325000-31350000~~chr21:31550000-31575000,
chr21:31343102-31344948~~chr21:31557869-31560689,
chr21:31346686-31348373~~chr21:31565575-31566814,
chr21:31346706-31348459~~chr21:31565524-31567074,
chr21:31350000-31375000~~chr21:31550000-31575000,
chr21:31450000-31475000~~chr21:31550000-31575000,