- Basic information
- CohesinDB ID: CDBP00416692
- Locus: chr21-31682687-31683516
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE126634, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000BTU, GSE93080, ENCSR000BKV, GSE138405, GSE76893, ENCSR703TNG, ENCSR000EEG, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000EDE, GSE126990, GSE50893, ENCSR000ECS
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Cell type: GM2610, GM19240, Liver, H9-hESC, RPE, GM2630, Ishikawa, HeLa-S3, K-562, GM18486, DKO, H1-hESC, GM12878, GM12891, GM2588, SK-N-SH, GM19193, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, A-549, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 13% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"4_Tx": 61%,
"5_TxWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, SNAPC1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, PAX8, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, TOP1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CD74, DACH1, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, HCFC1, MXI1, ZNF785, RELB, HCFC1R1, EP400, RUNX1, CEBPA, HDAC1, NKX2-2, IRF3, REPIN1, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, CBX4, SOX11, ZBTB10, TFDP1, ATF2, ELK1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, HMGB1, NFATC3, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, BRF2, SS18, ZSCAN16, WT1, MEF2C, MPHOSPH8, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, SRSF4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, INTS11, ELF1, ZNF573, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF350, PDX1, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZBTB17, ZSCAN21, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, CHD4, ONECUT1, KDM4A, HOMEZ, FOXP2, ZNF2, LHX2, RXRA, BATF3, NKX3-1, MIER3, LEF1, HNRNPH1, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF18, EWSR1, SP3, ARNT, BACH1, ZNF48, PRDM9, HMBOX1, ZEB2, NFYA, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, ETV6, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, ZNF768, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, SPIN1, CUX1, ZSCAN23, TBX2, ZFP42, PGR, FANCL, SOX2, PATZ1, RING1B, UBTF, LEO1, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, TP73, ZNF524, KLF1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ZNF76, ZNF554, NFYB, NCOA2, ETV5, GTF2A2, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, RARA, NFYC, CREBBP, ZNF35, TAF15, ZNF384, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, KMT2D, ZBTB16, ZNF324, RBAK, HEXIM1, ZZZ3, AHR, DMAP1, FOSL2, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, GLYR1, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, MBD4, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, HINFP, GATAD1, GMEB2, ARID3A, ZNF300, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ARNTL, ZNF750, FEZF1, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, CBX1, SMC1A, MAFG, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, SMAD2, ZNF184, ZSCAN30, OSR2, NRF1, PBX4, FOS, CHD1, SUPT5H, TGIF2, MED1, CEBPD, MYB, KDM6B, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NUP98-HOXA9, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): PAXBP1,SCAF4,SYNJ1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 15
- Number of somatic mutations (non-coding): 5
- Related genes and loops