- Basic information
- CohesinDB ID: CDBP00416736
- Locus: chr21-31799656-31801067
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Data sourse: GSE67783, GSE86191, GSE98367, ENCSR404BPV, GSE206145, GSE120943, ENCSR153HNT
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Cell type: RPE, HCT-116, Monocytes, Neurons-H1, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SMC1,SA1,Rad21,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
71% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 35%,
"14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, HMG20A, NME2, XBP1, FOXA1, HLF, SUZ12, RXRB, PBX2, MLL4, ZFHX2, TFAP4, ATF3, ZFP64, THAP1, ZBTB5, CHD7, TP63, ZSCAN4, ZNF467, TEAD1, KLF6, RBM39, RCOR2, ESR1, TP73, JUN, CTCF, ZBTB20, SOX5, FOXA3, ZNF175, GATAD2A, PDX1, TFAP2C, CHD8, ZSCAN5D, MYCN, ZNF263, POU5F1, TOP2A, ZBTB17, ZBTB48, ZSCAN5A, GATAD1, DDX5, SAP130, ERG2, ARID3A, HNF4G, ONECUT1, MYC, MCM5, RAD21, GRHL3, PROX1, NKX2-1, RXRA, GABPA, ZNF614, UBN1, MIER3, HNRNPH1, ARNTL, CEBPB, ESRRA, CREB1, EZH2, SPI1, TFE3, MIXL1, HDAC2, GATA2, ZNF644, FLI1, ZGPAT, NFIL3, RUNX1, THAP11, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, CRY1, SOX13, ZFX, SMAD3, TET2, ERG3, SP5, MCM2, RARA, ZNF384, CDK6, ARNT, ATF2, ZNF48, SMAD4, PRDM9, PBX3, MED1, TEAD3, CEBPD, MYB, SCRT2, BCL11A, ZSCAN31, ATF7, HNRNPLL, FOXP1, AATF, SMC3, NCOR2, STAG1, PAX7, SKI, TRP47, PPARG, FOXA2, TBL1X, CREM, MIER2, ZSCAN16, GTF2B, WT1, KDM1A, YY1, RELA, NEUROD1, MCM3, SP140, TCF4, HIF1A, GATA3, BATF, SPIB, GATA1, ZNF143, KLF4, CEBPG, ZFP69B, NR2F2, ZNF512, NR2F1, TP53, PKNOX1, ZNF334, MYOD1, EGR2, ELF3, KAT8, NFKBIZ, AR, ZNF366, EGR1, HSF1, NCOR1, RNF2, BRD4, JUND, SCRT1, CLOCK, CUX1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): MIS18A,HUNK
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 8
- Related genes and loops
- Related gene:
ENSG00000142149,
ENSG00000159055,
- Related loop:
chr21:10425000-10450000~~chr21:31775000-31800000,
chr21:31775000-31800000~~chr21:31875000-31900000,
chr21:31775000-31800000~~chr21:31950000-31975000,
chr21:31775000-31800000~~chr21:32175000-32200000,
chr21:31775000-31800000~~chr21:32225000-32250000,
chr21:31775000-31800000~~chr21:32250000-32275000,
chr21:31800000-31825000~~chr21:31950000-31975000,
chr21:31800000-31825000~~chr21:32225000-32250000,